Fig. 7

Time dependent changes in rectal [Hb] as assessed by PGS in mice grouped by blood supply level prior to tumor induction. Subset of AOM-treated mice (n = 16) were separated based on their absolute [Hb] compared to saline, RAS-unmodulated group (baseline) measured at wk. 2. AOM-treated mice within 30% of the mean rectal [Hb] in baseline group were considered similar to the baseline (blue line). Those with [Hb] < 70% baseline were grouped together as “Lower” blood supply (red line). Mice with lower [Hb] exhibited EIBS associated with tumor formation. AOM-treated mice with similar [Hb] to baseline did not show an increase in rectal [Hb] associated with tumors. Error bars represent standard error of the mean