Fig. 4

Rectal microvascular perfusion measured by PGS at indicated times during tumorigenesis. Total [Hb] was individually normalized per mouse by data recorded at week 0 for the (a) RAS-unmodulated; (b) AngII; and (c) Losartan groups. Mice were categorized based on colonoscopy reports of suspected lesions at 20 wks (Early tumor formers), 24 wks (Late tumor formers). The Early tumor formers in the (a) AOM alone group and (c) AOM + Losartan group exhibit an early increase in blood supply at wk. 12, a time-point preceding any visible tumors. Error bars represent standard error of the mean