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Fig. 4 | BMC Cancer

Fig. 4

From: Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers

Fig. 4

Loss of heterozygosity (LOH) of Cosmc and T-synthase in human CRCs. a, representative allele imbalance of Cosmc determined by single nucleotide polymorphism (SNP) combined PCR sequencing. SNP IDs are listed at the top in the order of their relative localizations in the Cosmc gene, and SNPs are indicated by arrows. Almost equal peak heights of SNPs were observed in the matched normal tissue, while one allele dramatically decreased in the tumor. ā€œrs?ā€ represents a previously undefined SNP. b, summary of the CRC samples with LOH in Cosmc. SNP IDs are listed on top, and the case IDs at left. Allele imbalance is indicated by black boxes. The plus and minus mark heterozygosity and homozygosity of a SNP in the normal tissue, respectively. c, LOH analyses of T-synthase. Representative SNP-PCR sequencing was shown in both adjacent normal and tumor specimens. SNP IDs are listed on top in the order of their relative localizations in the T-synthase gene, and SNPs are indicated by arrows. Almost equal peak heights of SNPs were observed in normal and tumor tissues

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