Table 5 Relative Expression and Survival Correlation of Mismatch Repair Genes
From: Examining transcriptional changes to DNA replication and repair factors over uveal melanoma subtypes
Gene | UVM Cluster 1 Above/Below Average (%/%) | UVM Cluster 2 Above/Below Average (%/%) | UVM Cluster 3 Above/Below Average (%/%) | UVM Cluster 4 Above/Below Average (%/%) | P Value 1&2 vs 3&4 Fisher’s Exact Two Tailed | Total Cases Above Average | Total Cases Below Average | Kaplan Meier Worse Survival | Kaplan Meier Log-rank |
|---|---|---|---|---|---|---|---|---|---|
n = 15 | n = 23 | n = 22 | n = 20 | ||||||
MLH1 | 11/4 (73/27) | 13/10 (57/43) | 7/15 (32/68) | 11/9 (55/45) | 0.0781 | 42 | 38 | NA | 0.9990 |
MLH3 | 6/9 (40/60) | 9/14 (39/61) | 12/10 (55/45) | 16/4 (80/20) | 0.0242 | 43 | 37 | NA | 0.3170 |
MSH2 | 7/8 (47/53) | 12/11 (52/48) | 9/13 (41/59) | 16/4 (80/20) | 0.5004 | 44 | 36 | NA | 0.7404 |
MSH3 | 8/7 (53/47) | 11/12 (48/52) | 9/13 (41/59) | 16/4 (80/20) | 0.5004 | 44 | 36 | NA | 0.3593 |
MSH6 | 4/11 (27/73) | 13/10 (57/43) | 10/12 (46/54) | 16/4 (80/20) | 0.0357 | 43 | 37 | NA | 0.7278 |
PMS1 | 6/9 (40/60) | 9/14 (39/61) | 9/13 (41/59) | 16/4 (80/20) | 0.1165 | 40 | 40 | NA | 0.3997 |
PMS2 | 8/7 (53/47) | 15/8 (65/35) | 11/11 (50/50) | 14/6 (70/30) | 1.0000 | 48 | 32 | NA | 0.7110 |
EXO1 | 8/7 (53/47) | 10/13 (43/57) | 4/18 (18/82) | 13/7 (65/35) | 0.6526 | 35 | 45 | NA | 0.4349 |