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Table 4 Relative Expression and Survival Correlation of Replisome and DNA Damage Response Factors

From: Examining transcriptional changes to DNA replication and repair factors over uveal melanoma subtypes

Gene

UVM Cluster 1 Above/Below Average (%/%)

UVM Cluster 2 Above/Below Average (%/%)

UVM Cluster 3 Above/Below Average (%/%)

UVM Cluster 4 Above/Below Average (%/%)

P Value 1&2 vs 3&4 Fisher’s Exact Two Tailed

Total Cases Above Average

Total Cases Below Average

Kaplan Meier Worse Survival

Kaplan Meier Log-rank

n = 15

n = 23

n = 22

n = 20

Replisome

PCNA

8/7 (40/60)

4/19 (17/83)

8/14 (36/64)

17/3 (85/15)

0.0147

37

43

Above

0.0280

FEN1

5/10 (33/67)

9/14 (39/61)

11/11 (50/50)

17/3 (85/15)

0.0132

42

38

Above

0.0884

LIG1

1/14 (7/93)

10/13 (44/56)

16/6 (73/27)

15/5 (75/25)

0.0001

42

38

NA

0.2590

POLD1

7/8 (47/53)

17/6 (74/26)

7/15 (32/68)

6/14 (30/70)

0.0067

37

43

Below

0.0597

POLE

4/11 (27/73)

14/9 (61/39)

11/11 (50/50)

16/4 (80/20)

0.1761

45

35

Above

0.0990

DNA Damage Response

HUS1

7/8 (47/53)

9/14 (39/61)

12/10 (55/45)

18/2 (90/10)

0.0124

46

34

Above

0.0278

RAD9A

9/6 (60/40)

10/13 (43/57)

13/9 (59/41)

16/4 (80/20)

0.1105

48

32

NA

0.8086

RAD1

8/7 (53/47)

10/13 (43/57)

10/12 (45/55)

16/4 (80/20)

0.2609

44

36

NA

0.1076

RAD17

8/7 (53/47)

9/14 (39/61)

9/13 (41/59)

16/4 (80/20)

0.2624

42

38

NA

0.5653

ATR

11/4 (73/27)

10/13 (44/56)

6/16 (27/73)

13/7 (65/35)

0.5021

40

40

NA

0.8707

CHEK1

4/11 (27/73)

8/15 (35/65)

12/10 (55/45)

15/5 (75/25)

0.0041

39

41

NA

0.3072

ATRIP

11/4 (73/27)

19/4 (83/17)

6/16 (27/73)

2/18 (10/90)

0.0001

38

42

Below

0.0001