From: Examining transcriptional changes to DNA replication and repair factors over uveal melanoma subtypes
Gene | UVM Cluster 1 Above/Below Average (%/%) | UVM Cluster 2 Above/Below Average (%/%) | UVM Cluster 3 Above/Below Average (%/%) | UVM Cluster 4 Above/Below Average (%/%) | P Value 1&2 vs 3&4 Fisher’s Exact Two Tailed | Total Cases Above Average | Total Cases Below Average | Kaplan Meier Worse Survival | Kaplan Meier Log-rank |
---|---|---|---|---|---|---|---|---|---|
n = 15 | n = 23 | n = 22 | n = 20 | ||||||
Replisome | |||||||||
PCNA | 8/7 (40/60) | 4/19 (17/83) | 8/14 (36/64) | 17/3 (85/15) | 0.0147 | 37 | 43 | Above | 0.0280 |
FEN1 | 5/10 (33/67) | 9/14 (39/61) | 11/11 (50/50) | 17/3 (85/15) | 0.0132 | 42 | 38 | Above | 0.0884 |
LIG1 | 1/14 (7/93) | 10/13 (44/56) | 16/6 (73/27) | 15/5 (75/25) | 0.0001 | 42 | 38 | NA | 0.2590 |
POLD1 | 7/8 (47/53) | 17/6 (74/26) | 7/15 (32/68) | 6/14 (30/70) | 0.0067 | 37 | 43 | Below | 0.0597 |
POLE | 4/11 (27/73) | 14/9 (61/39) | 11/11 (50/50) | 16/4 (80/20) | 0.1761 | 45 | 35 | Above | 0.0990 |
DNA Damage Response | |||||||||
HUS1 | 7/8 (47/53) | 9/14 (39/61) | 12/10 (55/45) | 18/2 (90/10) | 0.0124 | 46 | 34 | Above | 0.0278 |
RAD9A | 9/6 (60/40) | 10/13 (43/57) | 13/9 (59/41) | 16/4 (80/20) | 0.1105 | 48 | 32 | NA | 0.8086 |
RAD1 | 8/7 (53/47) | 10/13 (43/57) | 10/12 (45/55) | 16/4 (80/20) | 0.2609 | 44 | 36 | NA | 0.1076 |
RAD17 | 8/7 (53/47) | 9/14 (39/61) | 9/13 (41/59) | 16/4 (80/20) | 0.2624 | 42 | 38 | NA | 0.5653 |
ATR | 11/4 (73/27) | 10/13 (44/56) | 6/16 (27/73) | 13/7 (65/35) | 0.5021 | 40 | 40 | NA | 0.8707 |
CHEK1 | 4/11 (27/73) | 8/15 (35/65) | 12/10 (55/45) | 15/5 (75/25) | 0.0041 | 39 | 41 | NA | 0.3072 |
ATRIP | 11/4 (73/27) | 19/4 (83/17) | 6/16 (27/73) | 2/18 (10/90) | 0.0001 | 38 | 42 | Below | 0.0001 |