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Table 4 Relative Expression and Survival Correlation of Replisome and DNA Damage Response Factors

From: Examining transcriptional changes to DNA replication and repair factors over uveal melanoma subtypes

Gene UVM Cluster 1 Above/Below Average (%/%) UVM Cluster 2 Above/Below Average (%/%) UVM Cluster 3 Above/Below Average (%/%) UVM Cluster 4 Above/Below Average (%/%) P Value 1&2 vs 3&4 Fisher’s Exact Two Tailed Total Cases Above Average Total Cases Below Average Kaplan Meier Worse Survival Kaplan Meier Log-rank
n = 15 n = 23 n = 22 n = 20
Replisome
PCNA 8/7 (40/60) 4/19 (17/83) 8/14 (36/64) 17/3 (85/15) 0.0147 37 43 Above 0.0280
FEN1 5/10 (33/67) 9/14 (39/61) 11/11 (50/50) 17/3 (85/15) 0.0132 42 38 Above 0.0884
LIG1 1/14 (7/93) 10/13 (44/56) 16/6 (73/27) 15/5 (75/25) 0.0001 42 38 NA 0.2590
POLD1 7/8 (47/53) 17/6 (74/26) 7/15 (32/68) 6/14 (30/70) 0.0067 37 43 Below 0.0597
POLE 4/11 (27/73) 14/9 (61/39) 11/11 (50/50) 16/4 (80/20) 0.1761 45 35 Above 0.0990
DNA Damage Response
HUS1 7/8 (47/53) 9/14 (39/61) 12/10 (55/45) 18/2 (90/10) 0.0124 46 34 Above 0.0278
RAD9A 9/6 (60/40) 10/13 (43/57) 13/9 (59/41) 16/4 (80/20) 0.1105 48 32 NA 0.8086
RAD1 8/7 (53/47) 10/13 (43/57) 10/12 (45/55) 16/4 (80/20) 0.2609 44 36 NA 0.1076
RAD17 8/7 (53/47) 9/14 (39/61) 9/13 (41/59) 16/4 (80/20) 0.2624 42 38 NA 0.5653
ATR 11/4 (73/27) 10/13 (44/56) 6/16 (27/73) 13/7 (65/35) 0.5021 40 40 NA 0.8707
CHEK1 4/11 (27/73) 8/15 (35/65) 12/10 (55/45) 15/5 (75/25) 0.0041 39 41 NA 0.3072
ATRIP 11/4 (73/27) 19/4 (83/17) 6/16 (27/73) 2/18 (10/90) 0.0001 38 42 Below 0.0001