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Table 3 Relative Expression and Survival Correlation of Pre-Replication and Pre-Initiation Complex Factors

From: Examining transcriptional changes to DNA replication and repair factors over uveal melanoma subtypes

Gene UVM Cluster 1 Above/Below Average (%/%) UVM Cluster 2 Above/Below Average (%/%) UVM Cluster 3 Above/Below Average (%/%) UVM Cluster 4 Above/Below Average (%/%) P Value 1&2 vs 3&4 Fisher’s Exact Two Tailed Total Cases Above Average Total Cases Below Average Kaplan Meier Worse Survival Kaplan Meier Log-rank
n = 15 n = 23 n = 22 n = 20
Pre-Replication Complex
MCM2 12/3 (80/20) 20/3 (87/13) 3/19 (14/86) 5/15 (25/75) < 0.0001 40 40 Below 0.0001
MCM3 7/8 (47/53) 10/13 (43/57) 7/15 (32/68) 12/8 (60/40) 1.0000 36 44 NA 0.5514
MCM4 2/13 (13/87) 6/17 (26/74) 11/11 (50/50) 18/2 (90/10) < 0.0001 37 43 Above 0.0018
MCM5 9/6 (60/40) 16/7 (70/30) 11/11 (50/50) 4/16 (20/80) 0.0133 40 40 Below 0.0360
MCM6 6/9 (40/60) 9/14 (39/61) 15/7 (68/32) 19/1 (95/5) 0.0002 49 31 NA 0.1809
MCM7 3/12 (20/80) 17/6 (74/26) 11/11 (50/50) 11/9 (55/45) 1.0000 42 38 NA 0.2614
Pre-Initiation Complex
CDC45 5/10 (33/67) 6/17 (26/74) 14/8 (64/36) 15/5 (75/25) 0.0007 40 40 NA 0.4409
GINS1 5/10 (33/67) 8/15 (35/65) 6/16 (27/73) 15/5 (75/25) 0.1074 34 46 NA 0.1774
GINS2 8/7 (53/47) 11/12 (48/52) 14/8 64/36) 9/11 (45/55) 0.8229 42 38 NA 0.1965
GINS3 11/4 (73/27) 11/12 (48/52) 8/14 (36/64) 11/9 (55/45) 0.2735 41 39 NA 0.6131
GINS4 6/9 (40/60) 12/11 (52/48) 11/11 (50/50) 9/11 (45/55) 1.0000 38 42 NA 0.5714
MCM10 3/12 (20/80) 9/14 (39/61) 9/13 (41/59) 15/5 (75/25) 0.0261 36 44 NA 0.2409
CIZ1 12/3 (80/20) 15/8 (65/35) 13/9 (59/41) 2/18 (10/90) 0.0019 42 38 Below 0.0032