Table 3 Relative Expression and Survival Correlation of Pre-Replication and Pre-Initiation Complex Factors
From: Examining transcriptional changes to DNA replication and repair factors over uveal melanoma subtypes
Gene | UVM Cluster 1 Above/Below Average (%/%) | UVM Cluster 2 Above/Below Average (%/%) | UVM Cluster 3 Above/Below Average (%/%) | UVM Cluster 4 Above/Below Average (%/%) | P Value 1&2 vs 3&4 Fisher’s Exact Two Tailed | Total Cases Above Average | Total Cases Below Average | Kaplan Meier Worse Survival | Kaplan Meier Log-rank |
|---|---|---|---|---|---|---|---|---|---|
n = 15 | n = 23 | n = 22 | n = 20 | ||||||
Pre-Replication Complex | |||||||||
MCM2 | 12/3 (80/20) | 20/3 (87/13) | 3/19 (14/86) | 5/15 (25/75) | < 0.0001 | 40 | 40 | Below | 0.0001 |
MCM3 | 7/8 (47/53) | 10/13 (43/57) | 7/15 (32/68) | 12/8 (60/40) | 1.0000 | 36 | 44 | NA | 0.5514 |
MCM4 | 2/13 (13/87) | 6/17 (26/74) | 11/11 (50/50) | 18/2 (90/10) | < 0.0001 | 37 | 43 | Above | 0.0018 |
MCM5 | 9/6 (60/40) | 16/7 (70/30) | 11/11 (50/50) | 4/16 (20/80) | 0.0133 | 40 | 40 | Below | 0.0360 |
MCM6 | 6/9 (40/60) | 9/14 (39/61) | 15/7 (68/32) | 19/1 (95/5) | 0.0002 | 49 | 31 | NA | 0.1809 |
MCM7 | 3/12 (20/80) | 17/6 (74/26) | 11/11 (50/50) | 11/9 (55/45) | 1.0000 | 42 | 38 | NA | 0.2614 |
Pre-Initiation Complex | |||||||||
CDC45 | 5/10 (33/67) | 6/17 (26/74) | 14/8 (64/36) | 15/5 (75/25) | 0.0007 | 40 | 40 | NA | 0.4409 |
GINS1 | 5/10 (33/67) | 8/15 (35/65) | 6/16 (27/73) | 15/5 (75/25) | 0.1074 | 34 | 46 | NA | 0.1774 |
GINS2 | 8/7 (53/47) | 11/12 (48/52) | 14/8 64/36) | 9/11 (45/55) | 0.8229 | 42 | 38 | NA | 0.1965 |
GINS3 | 11/4 (73/27) | 11/12 (48/52) | 8/14 (36/64) | 11/9 (55/45) | 0.2735 | 41 | 39 | NA | 0.6131 |
GINS4 | 6/9 (40/60) | 12/11 (52/48) | 11/11 (50/50) | 9/11 (45/55) | 1.0000 | 38 | 42 | NA | 0.5714 |
MCM10 | 3/12 (20/80) | 9/14 (39/61) | 9/13 (41/59) | 15/5 (75/25) | 0.0261 | 36 | 44 | NA | 0.2409 |
CIZ1 | 12/3 (80/20) | 15/8 (65/35) | 13/9 (59/41) | 2/18 (10/90) | 0.0019 | 42 | 38 | Below | 0.0032 |