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Fig. 4 | BMC Cancer

Fig. 4

From: Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins

Fig. 4

Gn down-regulates Notch/Wnt signaling. In HCT-116 and DLD1 cells, Notch and Wnt target genes expression in protein (a) and mRNA (b) levels were altered upon drug treatment. For protein detection, cells were collected 48 h after drug treatment; for real-time RCR, cells were collected 24 h after treatment. c TOP flash Wnt signaling reporter assay was carried out in HCT-116 cells with DMSO or different doses of drugs. In all Figures, ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05 versus DMSO control. MP-Gr or DMSO treatment is consistent with our early report [27]

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