Fig. 3
From: Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins
Gn induces apoptosis and autophagy in colon cancer cell lines. a PARP cleavage was observed in colon cancer cell lines treated with different doses of Gn for 48 h. MP-Gr or DMSO treatment had no effect, consistent with our early report [27]. b Caspase-3 activity was increased in Gn treated cells. MP-Gr or DMSO treatment had no effect, consistent with our early report [27]. (n = 2). ***p < 0.001 versus DMSO control. c Representative images of Gn or DMSO treated DLD-1 cells from time lapse videos. d DLD-1 cells were treated with Gn or DMSO, in the presence or absence of chloroquine (CQ, 50 nM) pretreatment for 16 h