TY - JOUR AU - Kordowski, Felix AU - Kolarova, Julia AU - Schafmayer, Clemens AU - Buch, Stephan AU - Goldmann, Torsten AU - Marwitz, Sebastian AU - Kugler, Christian AU - Scheufele, Swetlana AU - Gassling, Volker AU - Németh, Christopher G. AU - Brosch, Mario AU - Hampe, Jochen AU - Lucius, Ralph AU - Röder, Christian AU - Kalthoff, Holger AU - Siebert, Reiner AU - Ammerpohl, Ole AU - Reiss, Karina PY - 2018 DA - 2018/08/06 TI - Aberrant DNA methylation of ADAMTS16 in colorectal and other epithelial cancers JO - BMC Cancer SP - 796 VL - 18 IS - 1 AB - ADAMs (a disintegrin and metalloproteinase) have long been associated with tumor progression. Recent findings indicate that members of the closely related ADAMTS (ADAMs with thrombospondin motifs) family are also critically involved in carcinogenesis. Gene silencing through DNA methylation at CpG loci around e.g. transcription start or enhancer sites is a major mechanism in cancer development. Here, we aimed at identifying genes of the ADAM and ADAMTS family showing altered DNA methylation in the development or colorectal cancer (CRC) and other epithelial tumors. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-018-4701-2 DO - 10.1186/s12885-018-4701-2 ID - Kordowski2018 ER -