Table 2 Risk of second primary cancer after primary POFT cancer diagnosis by age and follow-up period
Total | Age (years) | Follow-up (months) | ||||||
|---|---|---|---|---|---|---|---|---|
< 60 | ≥60 | 2–59 | 60–119 | ≥120 | ||||
SIR | O/E | CI | SIR | SIR | SIR | SIR | SIR | |
Leukaemia | 3.07# | (22/7.16) | (1.92–4.65) | 3.86# | 1.60 | 3.16# | 3.68# | 2.05 |
Urinary bladder | 1.99 | (10/5.03) | (0.95–3.66) | 2.90# | 1.35 | 2.01 | 2.93 | 0.85 |
Lung, bronchus | 1.80# | (81/44.89) | (1.43–2.24) | 2.61# | 1.01 | 1.26 | 2.64# | 1.99# |
Rectum, rectosigmoid junction | 1.42# | (47/33.04) | (1.05–1.89) | 1.67# | 1.08 | 1.53 | 1.35 | 1.27 |
Thyroid | 1.34# | (206/153.16) | (1.17–1.54) | 1.35# | 1.32 | 1.57# | 1.21 | 0.95 |
Colon | 1.58# | (122/77.38) | (1.31–1.88) | 2.00# | 1.03 | 1.69# | 1.34 | 1.60# |
Ascending colon | 1.77# | (25/14.14) | (1.14–2.61) | 2.26# | 1.28 | 1.60 | 1.31 | 2.61# |
Transverse colon | 2.43# | (14/5.77) | (1.33–4.07) | 4.07# | 0.71 | 1.79 | 1.93 | 4.22# |
Descending colon | 1.17 | (23/19.64) | (0.74–1.76) | 1.43 | 0.77 | 1.52 | 1.50 | 0.00# |
Rectum | 1.45# | (48/33.13) | (1.07–1.92) | 1.72# | 1.08 | 1.52 | 1.34 | 1.40 |
Other and unspecified | 2.55# | (12/4.71) | (1.32–4.45) | 4.01# | 1.21 | 3.74# | 0.00 | 2.94 |
Female breast | 1.26# | (128/101.85) | (1.05–1.49) | 1.30# | 0.99 | 1.29# | 1.47# | 0.87 |
Kidney parenchyma | 1.43 | (12/8.37) | (0.74–2.50) | 1.49 | 1.34 | 1.64 | 1.78 | 0.54 |
Renal pelvis, other urinary | 2.38 | (5/2.10) | (0.77–5.56) | 2.31 | 2.43 | 3.02 | 0.00 | 3.69 |
Pancreas | 1.25 | (20/15.94) | (0.77–1.94) | 1.72 | 0.89 | 0.91 | 2.55# | 0.51 |
Non-Hodgkin lymphoma | 0.88 | (11/12.43) | (0.44–1.58) | 1.13 | 0.45 | 1.09 | 0.60 | 0.74 |
Bile ducts, other biliary | 1.43 | (26/18.23) | (0.93–2.09) | 2.20# | 0.86 | 1.57 | 1.01 | 1.61 |
Stomach | 0.89 | (67/75.35) | (0.69–1.13) | 1.15 | 0.55# | 0.56# | 1.34 | 1.15 |
Liver | 0.68 | (16/23.54) | (0.39–1.1) | 0.81 | 0.50 | 0.71 | 0.48 | 0.86 |
Gallbladder | 0.64 | (6/9.43) | (0.23–1.38) | 1.21 | 0.19 | 0.64 | 0.39 | 0.92 |
Small intestine | 1.93 | (4/2.07) | (0.53–4.94) | 3.37 | 0.00 | 1.89 | 0.00 | 4.38 |
All excluding POFT | 1.29# | (838/647.47) | (1.21–1.38) | 1.47# | 0.91 | 1.33# | 1.38# | 1.11 |