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Table 1 Patient demographics

From: Safety and tolerability of quizartinib, a FLT3 inhibitor, in advanced solid tumors: a phase 1 dose-escalation trial

 

Treatment group, 90 mg (n = 8)

Treatment group, 135 mg (n = 5)

Total (N = 13)

Age, years

 Mean (SD)

50.3 (16.05)

53.6 (9.56)

51.5 (13.55)

 Median

49.5

56.0

50.0

 Min, Max

26, 75

43, 66

26, 75

Age category, n (%)

 18–60 years

6 (75.0)

4 (80.0)

10 (76.9)

 61–75 years

2 (25.0)

1 (20.0)

3 (23.1)

Male, n (%)

3 (37.5)

2 (40.0)

5 (38.5)

Female, n (%)

5 (62.5)

3 (60.0)

8 (61.5)

Race, n (%)

 White

7 (87.5)

4 (80.0)

11 (84.6)

 Asian

0

1 (20.0)

1 (7.7)

 Missing

1 (12.5)

0

1 (7.7)

Ethnicity, n (%)

 Hispanic or Latino

2 (25.0)

2 (40.0)

4 (30.8)

 Not Hispanic or Latino

6 (75.0)

3 (60.0)

9 (69.2)

ECOG performance status, Cycle 1/Day 1, n (%)

 0

4 (50.0)

2 (40.0)

6 (46.2)

 1

4 (50.0)

3 (60.0)

7 (53.8)

Prior chemotherapy, n (%)

5 (62.5)

4 (80.0)

9 (69.2)

Prior TKI therapy, n (%)

4 (50.0)

3 (60.0)

7 (53.8)

Tumor type, n

 GIST

3

0

3

 Sarcoma

2

1

3

 Thyroid cancer

1

1

2

 Colorectal cancer

1

1

2

 Gall bladder cancer

0

1

1

 Melanoma

1

0

1

 Unknown primary tumor

0

1

1

  1. ECOG Eastern Cooperative Oncology Group, GIST gastrointestinal stromal tumor, SD standard deviation, TKI tyrosine kinase inhibitor