Fig. 8
From: Loss of PDPK1 abrogates resistance to gemcitabine in label-retaining pancreatic cancer cells
Comparison of PDPK1 expression in pancreatic tissue microarray. a Representative photomicrographs of pancreatic tissue microarray (TMA) cores illustrating expression levels of PDPK1 immunohistochemical staining (0,1+,2+,3+) and examples of cytoplasmic and membranous PDPK1 staining (arrows). b Reduced PDPK1 expression levels in tumor specimens compared to matched normal (uninvolved) pancreatic tissue (Wilcoxon matched-pairs signed rank test; p < 0.0001). c Membranous staining is more frequent in well-differentiated tumors (p = 0.0029, Fisher’s exact test). d Trend (log-rank test; p = 0.3063) towards improved survival in patients who showed membranous PDPK1 staining