Table 1 Cancer associated circRNAs
Cancer type | CircRNA | Samples | Cases | Expression | Association | Reference |
|---|---|---|---|---|---|---|
Bladder cancer | CircPTK2 | Tissue/blood | 40 pairs | Up | Poor differentiation, higher lymph node metastasis and T stage | [83] |
Circ-ITCH | Tissue | 72 pairs | Down | Higher TNM stage and histological grade | [96] | |
Esophageal cancer | Has_circ_0067934 | Tissue | 51 pairs | Up | Poor differentiation and higher TNM stage | [84] |
CiRS-7 | Tissue | 86 pairs | Up | Higher clinical stage and pathological grade | [97] | |
Colorectal cancer | Hsa_circ_0007534 | Tissue | 33 pairs | Up | Higher clinical stage and lymph node metastasis | [68] |
Hsa_circ_001988 | Tissue | 31 pairs | Down | Associated with differentiation and perineural invasion | [67] | |
Hsa_circ_0000069 | Tissue | 30 pairs | Up | Associated with patient age and TNM stage | [98] | |
CiRS-7 | Tissue | 40 pairs | Up | Higher T-stage and metastasis/poor prognosis | [70] | |
Circular BANP | Tissue | 35 pairs | Up | Unknown | [41] | |
CircRNA0003906 | Tissue | 122 pairs | Down | Poor differentiation, higher lymphatic metastasis/diagnosis value | [99] | |
Hsa_circ_0001649 | Tissue/blood | Total 146 | Down (tissue)/up (blood) | Associated with differentiation | [100] | |
Circ_0014717 | Tissue | 46 pairs | Down | Associated with TNM stage and distal metastasis/poor prognosis | [69] | |
Hsa_circ_0000567 | Tissue | 102 pairs | Down | Lower clinical stage and lymph node metastasis/diagnosis value | [101] | |
CircHIPK3 | Tissue | Total 218 | Up | Associated with TNM stage and metastasis/poor prognosis | [102] | |
Hepatocellular carcinoma | CiRS-7 | Tissue | 108 pairs | Up (39.8%)/down (60.2%) | Associated with MVI | [103] |
Hsa_circ_0005075 | Tissue | 66 pairs | Up | Larger size tumors/diagnostic potential | [75] | |
Hsa_circ_0001649 | Tissue | 89 pairs | Down | Larger tumor size and tumor embolus formation/poor prognosis | [104] | |
Hsa_circ_0003570 | Tissue | 107 pairs | Down | Associated with tumor diameter, differentiation and vascular formation | [73] | |
CircMTO1 | Tissue | 261 pairs | Down | Poor prognosis | [74] | |
CircZKSCAN1 | Tissue | 102 pairs | Down | Potential diagnostic value | [76] | |
Hsa_circ_0000673 | Tissue | 51 pairs | Up | Poor overall survival | [105] | |
CircC3P1 | Tissue | 47 pairs | Down | Higher TNM stage, tumor size and vascular invasion | [106] | |
Gastric cancer | Hsa_circ_002059 | Tissue/plasma | Total 147 | Down | Associated with distal metastasis, TNM stage, gender and age | [11] |
Hsa_circ_0000190 | Tissue/plasma | 104 pairs | Down | Associated with tumor diameter, metastasis and TNM stage (tissue)/CEA (plasma) | [81] | |
Circ-104916 | Tissue | 70 pairs | Down | Higher tumor stage and lymphatic metastasis | [80] | |
CircRNA_100269 | Tissue | 112 pairs | Down | Associated with histological subtypes and nodes invasion | [107] | |
Hsa_circ_0000745 | Tissue/plasma | 20 pairs | Down | Associated with tumor differentiation (tissue)/node metastasis (plasma) | [108] | |
Hsa circ 0074362 | Tissue | 127 pairs | Down | Associated with CA19–9 and lymphatic metastasis | [109] | |
CircPVT1 | Tissue | 187 pairs | Up | Associated with overall survival | [110] | |
Hsa_circ_0006633 | Tissue/plasma | Total 338 | Down(tissue)/up(plasma) | Associated with distal metastasis and CEA (tissue) | [78] | |
Hsa_circ_0001895 | Tissue | Total 257 | Down | Associated with differentiation, Borrmann type and CEA | [111] | |
Hsa_circ_0014717 | Tissue/gastric juice | Total 122 | Down | Associated with tumor stage, metastasis, CEA and CA19–9 (tissue) | [79] | |
Hsa_circ_0003159 | Tissue | 108 pairs | Down | Higher gender, distal metastasis and node metastasis | [112] | |
Hsa_circ_0000181 | Tissue/plasma | Total 115 | Down | Associated with tumor diameter, metastasis and CA19–9 (tissue)/differentiation and CEA | [82] | |
Hsa_circ_0000520 | Tissue | 56 pairs | Down | Higher TNM stage | [113] | |
CircMYO9B | Tissue | 21 pairs | Up | Lower survival rate | [114] | |
Breast cancer | CircGFRA1 | Tissue | Total 222 | Up | Higher tumor size, TNM stage, lymphatic metastasis and histological grade | [115] |
Cir-ITCH | Tissue | Total 78 | Up | Associated with age | [58] | |
CircRNA_100876 | Tissue | 101 pairs | Up | Associated with lymphatic metastasis and advanced stage | [116] | |
Osteosarcoma | CircPVT1 | Tissue/serum/lung metastasis | Total 80 | Up | Poor prognosis/diagnosis value | [95] |
Lung cancer | CircFADS2 | Tissue | 43 pairs | Up | Poor differentiation, advanced TNM stage and lymphatic metastasis | [117] |
CircRNA_102231 | Tissue | 57 pairs | Up | Associated with TNM stage and lymph node metastasis | [118] |