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Table 2 Univariate and Multivariate Models for Overall Survival in Patients with GBM in the Cancer Genome Atlas (TCGA) Cohorta

From: Clinical significance of FBXO17 gene expression in high-grade glioma

Overall Survival

Univariate analysis

Multivariate analysisd

HR (95%CI)c

P Valuee

HR (95%CI)c

P Valuee

IDH1 mut + wt cases (n = 311)b

 FBXO17 expression

1.47 (1.24–1.74)

< 0.0001

1.29 (1.04 --1.59)

0.018

IDH1 status

 Wild-type (288)

1 [Reference]

 

1 [Reference]

 

 Mutation (23)

0.38 (0.21–0.68)

0.001

0.62 (0.31 --1.25)

0.179

Sex

 Female (113)

1 [Reference]

 

1 [Reference]

 

 Male (198)

1.11 (0.85–1.45)

0.451

1.18 (0.90 --1.55)

0.216

Age, years

 < 60 (164)f

1 [Reference]

 

1 [Reference]

 

 ≥ 60 (147)

1.74 (1.34 -- 2.26)

< 0.0001

1.56 (1.20 -- 2.03)

0.001

IDH1 wt cases alone (n = 288)

FBXO17 expression

1.33 (1.08–1.64)

0.007

1.26 (1.02 --1.56)

0.034

Sex

    

 Female (106)

1 [Reference]

 

1 [Reference]

 

 Male (182)

1.23 (0.94–1.62)

0.138

1.23 (0.94 --1.62)

0.139

Age, years

 < 60 (144)

1 [Reference]

 

1 [Reference]

 

 ≥ 60 (144)

1.69 (1.29 -- 2.21)

< 0.0001

1.59 (1.21 -- 2.09)

0.001

  1. aIncluded are data from the 311 TCGA GBM patients who had all the following data available such as FBXO17 gene expression, IDH1 mutation, gender, age, survival time, and vital status. The numbers in parentheses denote the numbers of patients in the specified subgroups
  2. bwt, wide-type; mut, mutant
  3. cHR, hazard ratio; CI, confidence interval
  4. dBased on a multivariate Cox proportional hazards model, including all variables in the table
  5. eWald’s test, P values
  6. fThe median age of the common set is 60 years
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BMC Cancer

ISSN: 1471-2407

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