Table 1 Summary of dose escalation
Dose-level | Number of patients enrolled | Number of patients evaluable for DLT | Number of patients with DLT | Details regarding the observed DLTs |
|---|---|---|---|---|
1 (40 mg/m2) | 3 | 3 | 0 | – |
2 (60 mg/m2) | 7 | 6 | 1 | Peripheral neuropathy |
3 (70 mg/m2) | 4 | 3 | 0 | – |
4 (75 mg/m2) | 4 | 4 | 2 | Febrile neutropenia |
Leucopenia not allowing paclitaxel administration | ||||
Expansion (70 mg/m2) | 10 | 10 | 1 | Leucopenia not allowing paclitaxel administration |