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Table 1 Summary of dose escalation

From: Once weekly paclitaxel associated with a fixed dose of oral metronomic cyclophosphamide: a dose-finding phase 1 trial

Dose-level Number of patients enrolled Number of patients evaluable for DLT Number of patients with DLT Details regarding the observed DLTs
1 (40 mg/m2) 3 3 0
2 (60 mg/m2) 7 6 1 Peripheral neuropathy
3 (70 mg/m2) 4 3 0
4 (75 mg/m2) 4 4 2 Febrile neutropenia
Leucopenia not allowing paclitaxel administration
Expansion (70 mg/m2) 10 10 1 Leucopenia not allowing paclitaxel administration