Table 1 IC-50 and genetic rearrangements for AML cell lines tested
Genetic rearrangement | Cell lines | IC50 (nM) |
|---|---|---|
t (4;11) (q21; q23) | MOLM-14 | 45 |
t (8;21) (q22; q22) | Kasumi-1 | 222 |
t (4;11) (q21; q23) | MV4-11 | 245 |
hypodiploid | OCI-AML3 | 260 |
hypodiploid | OCI-AML2 | 309 |
t (10;11) (p12; q14) | U937 | 569 |
hypodiploid | KG1a | 628 |
t (15;17) (q22; q12) | NB4 | 710 |
hypodiploid | KG1 | 775 |
hypodiploid | HL-60 | 1222 |