|
MANCOVA
|
MANCOVA
|
ANOVA
|
|---|
|
Protein
|
COPD (n = 42) vs LC (n = 207)
|
BC-sign
|
COPD / LConly / LCcopd
|
BC-sign
|
COPD vs LCcopd
|
COPD vs LConly
|
LCcopd vs LConly
|
|
OPG
|
p < 0.001
|
Sign.
|
p < 0.001
|
Sign.
|
p < 0.001
|
p < 0.001
|
ns
|
|
PTX3
|
p = 0.001
|
Sign.
|
p = 0.002
|
Sign.
|
p = 0.04
|
p = 0.001
|
ns
|
|
Axl
|
p < 0.001
|
Sign.
|
p < 0.001
|
Sign.
|
p < 0.001
|
p = 0.002
|
ns
|
|
CXCL16
|
p = 0.019
|
ns
|
p = 0.005
|
ns
|
ns
|
p = 0.002
|
p = 0.023
|
|
Alcam (CD166)
|
p < 0.001
|
Sign.
|
p < 0.001
|
Sign.
|
p < 0.001
|
p < 0.001
|
ns
|
|
sCD163
|
p = 0.001
|
Sign.
|
p = 0.001
|
Sign.
|
ns
|
p = 0.01
|
ns
|
|
CD147
|
p < 0.001
|
Sign.
|
p < 0.001
|
Sign.
|
p < 0.001
|
p < 0.001
|
ns
|
|
Endostatin
|
ns
|
ns
|
p = 0.005
|
ns
|
ns
|
ns
|
p = 0.033
|
|
Cats
|
p = 0.002
|
Sign.
|
p = 0.004
|
ns
|
p = 0.029
|
p = 0.004
|
ns
|
|
CRP
|
ns
|
ns
|
p = 0.004
|
ns
|
p = 0.018
|
ns
|
p = 0.001
|
|
DLL1
|
p < 0.001
|
Sign.
|
p < 0.001
|
Sign.
|
p < 0.001
|
p < 0.001
|
ns
|
- ANOVA and MANCOVA analyses comparing circulating protein levels in patients with COPD and patients with lung cancer with and without COPD. One-way MANCOVA was performed on two groups (COPD and Lung cancer with and without COPD), and on three groups (COPD, lung cancer with COPD and lung cancer without COPD). One-way ANOVA was conducted to explore the differences in the levels of proteins between the three groups; COPD (n = 42), lung cancer with COPD (n = 116) and lung cancer without COPD (n = 92). Multiple testing is controlled for by Bonferroni correction. Only significant markers are shown
