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Table 3 Serum protein levels in lung cancer patients and COPD patients. LCCOPD –lung cancer with COPD. LConly –lung cancer with and without COPD

From: Levels and prognostic impact of circulating markers of inflammation, endothelial activation and extracellular matrix remodelling in patients with lung cancer and chronic obstructive pulmonary disease

MANCOVA

MANCOVA

ANOVA

Protein

COPD (n = 42) vs LC (n = 207)

BC-sign

COPD / LConly / LCcopd

BC-sign

COPD vs LCcopd

COPD vs LConly

LCcopd vs LConly

OPG

p < 0.001

Sign.

p < 0.001

Sign.

p < 0.001

p < 0.001

ns

PTX3

p = 0.001

Sign.

p = 0.002

Sign.

p = 0.04

p = 0.001

ns

Axl

p < 0.001

Sign.

p < 0.001

Sign.

p < 0.001

p = 0.002

ns

CXCL16

p = 0.019

ns

p = 0.005

ns

ns

p = 0.002

p = 0.023

Alcam (CD166)

p < 0.001

Sign.

p < 0.001

Sign.

p < 0.001

p < 0.001

ns

sCD163

p = 0.001

Sign.

p = 0.001

Sign.

ns

p = 0.01

ns

CD147

p < 0.001

Sign.

p < 0.001

Sign.

p < 0.001

p < 0.001

ns

Endostatin

ns

ns

p = 0.005

ns

ns

ns

p = 0.033

Cats

p = 0.002

Sign.

p = 0.004

ns

p = 0.029

p = 0.004

ns

CRP

ns

ns

p = 0.004

ns

p = 0.018

ns

p = 0.001

DLL1

p < 0.001

Sign.

p < 0.001

Sign.

p < 0.001

p < 0.001

ns

  1. ANOVA and MANCOVA analyses comparing circulating protein levels in patients with COPD and patients with lung cancer with and without COPD. One-way MANCOVA was performed on two groups (COPD and Lung cancer with and without COPD), and on three groups (COPD, lung cancer with COPD and lung cancer without COPD). One-way ANOVA was conducted to explore the differences in the levels of proteins between the three groups; COPD (n = 42), lung cancer with COPD (n = 116) and lung cancer without COPD (n = 92). Multiple testing is controlled for by Bonferroni correction. Only significant markers are shown