Table 1 Characteristics of studies included in the meta-analysis
Author | Year | Region | Type of Cancer | Sample size (high/low) | Follow-up (month) | Endpoints | Expression associated with poor prognosis | Assay method | Cut-off value | Survival analysis | NOS score | Method |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Zhu et al. | 2017 | China | Breast Cancer | 27/47(74) | 94 | OS | Low | IHC | High: the sum of the staining intensity and extent scores was higher than 3 | NA | 6 | 2 |
Zhai et al. | 2016 | China | Gastric Caner | 50/67(117) | 114 | OS | Low | IHC | High: IHC score was no less than 2 | Univariate Multivariate | 7 | 2 |
Ruan et al. | 2015 | China | Cervical Squamous Cell Carcinoma | 25/29(54) | 80 | OS | Low | IHC | High: the sum of the staining intensity and extent scores was no less than 4 | NA | 6 | 2 |
He et al. | 2013 | China | Ovarian Cancer | 75/78(153) | 102 | OS,DFS | Low | IHC | High: the sum of the staining intensity and extent scores was no less than 4 | Univariate Multivariate | 7 | 1 |
Li et al. | 2016 | China | Colon Cancer | 83/52(135) | 95.3 | OS,RFS | Low | IHC | High: the sum of the staining intensity and extent scores was no less than 4 | Univariate Multivariate | 7 | 1 |
Colbert et al. | 2013 | USA | Pancreatic Adenocarcinoma | 74/6(80) | 114 | OS,RFS | Low | IHC | High: the sum of the staining intensity and extent scores was higher than 1 | Univariate Multivariate | 7 | 1 |