Skip to main content

Table 3 Relationship of four classes based on PD-L1 expression and CD8+ TILs

From: Classification of gallbladder cancer by assessment of CD8+ TIL and PD-L1 expression

Ā 

Subgroup I

Subgroup II

Subgroup III

Subgroup IV

Ā 

CD8high

PD-L1āˆ’

CD8high

PD-L1+

CD8low

PD-L1āˆ’

CD8low

PD-L1+

Clinical parameters

n (%)

(nā€‰=ā€‰12)

(nā€‰=ā€‰21)

(nā€‰=ā€‰18)

(nā€‰=ā€‰15)

Age median (range)

65 (50ā€“79)

64 (29ā€“75)

66 (48ā€“79)

70 (45ā€“81)

Sex (Female)

7 (58%)

12 (57%)

10 (56%)

9 (60%)

TNM stage (IIIā€‰+ā€‰IV)

7 (58%)

11 (52%)

14 (78%)

11 (73%)

Risk factors

ā€ƒGallstone

3 (25%)

13 (62%)

11 (61%)

9 (60%)

ā€ƒDiabetes

4 (33%)

6 (29%)

7 (39%)

3 (20%)

ā€ƒHypertension

4 (33%)

8 (38%)

8 (44%)

5 (33%)

ā€ƒCholecystitis

7 (58%)

12 (57%)

14 (78%)

10 (67%)

Jaundice

0 (0%)

6 (29%)

4 (22%)

4 (27%)

Completed resection

8 (67%)

16 (76%)

11 (61%)

11 (73%)

CEA (>ā€‰ 5Ā Ī¼g/L)

2 (17%)

5 (24%)

4 (22%)

9 (60%)

CA19ā€“9 (>ā€‰ 34Ā U/mL)

4 (33%)

13 (62%)

11 (61%)

7 (58%)

Liver dysfunction

ā€ƒALT (>ā€‰ 40Ā U/L)

Ā Ā Ā Ā 

ā€ƒAST (>ā€‰ 35Ā U/L)

1 (8%)

5 (24%)

5 (28%)

4 (27%)

ā€ƒTBil (>ā€‰ 22.2Ā Ī¼mol/L)

3 (25%)

5 (24%)

6 (33%)

5 (33%)

ā€ƒDBil (>ā€‰ 6.8Ā Ī¼mol/L)

3 (25%)

7 (33%)

5 (28%)

5 (33%)

ā€ƒGGT (>ā€‰ 45Ā U/L)

1 (8%)

7 (33%)

5 (28%)

5 (33%)

ā€ƒALP (>ā€‰ 135Ā U/L)

3 (25%)

7 (33%)

5 (28%)

5 (33%)

Ā 

2 (17%)

9 (43%)

5 (28%)

4 (27%)

Pathological features

Differentiation (Poor)

5 (42%)

12 (57%)

9 (50%)

12 (80%)

Tumor size, cm (median, range)

2.4 (0.6ā€“7.5)

3.5 (0.5ā€“7.0)

3.0 (0.6ā€“6.0)

2.0 (0.8ā€“7.0)

Immunohistochemistry

ā€ƒCD133+ in TCs, n (%)

5 (42%)

9 (43%)

6 (33%)

7 (58%)

ā€ƒPD-1+ in TILs, n (%)

7 (58%)

9 (43%)

6 (33%)

11 (73%)

ā€ƒPD-L2+ in TCs, n (%)

5 (42%)

17 (81%)

9 (50%)

13 (87%)

ā€ƒCD8+ TILs density

60.5

79

28

27

ā€ƒ(median, range)

(47ā€“167)

(49ā€“275)

(4ā€“42)

(8ā€“46)

Adjuvant treatment

ā€ƒChemotherapy, n (%)

7 (58%)

12 (57%)

13 (72%)

8 (53%)

ā€ƒRadiotherapy, n (%)

2 (17%)

5 (24%)

4 (22%)

4 (27%)

ā€ƒOthers, n (%)

3 (25%)

8 (33%)

6 (33%)

4 (27%)

ā€ƒNo, n (%)

2 (17%)

4 (19%)

2 (11%)

2 (13%)

Palliative treatment at stage IV

ā€ƒWith therapy, n (%)

8 (67%)

16 (76%)

15 (83%)

12 (80%)

ā€ƒWithout therapy, n (%)

4 (33%)

5 (24%)

3 (17%)

3 (20%)