Classification of gallbladder cancer by assessment of CD8+ TIL and PD-L1 expression

BMC Cancer

Table 2 Multivariate analysis factors associated with PFS or OS

	Hazard Ratio	95% CI	P-value
Overall survival (OS)
TNM stage (I + II vs. III + IV)	2.29	1.14–4.58	0.019
Completed resection (no v yes)	0.36	0.17–0.75	0.006
Classification based on PD-L1 expression and CD8⁺ TILs
Overall	NA	NA	< 0.001
I vs. II	3.71	1.32–10.41	0.013
I vs. III	2.06	0.72–5.85	0.177
I vs. IV	9.60	3.20–28.84	0.001
Progression-free survival (PFS)
Completed resection (no v yes)	0.40	0.22–0.72	0.002
Classification based on PD-L1 expression and CD8⁺ TILs
Overall	NA	NA	0.014
I vs. II	2.61	1.12–6.09	0.027
I vs. III	2.15	0.89–5.20	0.090
I vs. IV	4.99	1.87–13.31	0.001

Note: Multivariate analysis, Cox proportional hazards regression model (based on Wald Forward selection)
Variables were adopted for their prognostic significance by univariate analysis
Subgroups: I (CD8^high&PD-L1⁻); II (CD8^high&PD-L1⁺); III (CD8^low&PD-L1⁻); IV (CD8^low&PD-L1⁺)

ISSN: 1471-2407