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Table 2 Multivariate analysis factors associated with PFS or OS

From: Classification of gallbladder cancer by assessment of CD8+ TIL and PD-L1 expression

  Hazard Ratio 95% CI P-value
Overall survival (OS)
TNM stage (I + II vs. III + IV) 2.29 1.14–4.58 0.019
Completed resection (no v yes) 0.36 0.17–0.75 0.006
Classification based on PD-L1 expression and CD8+ TILs
 Overall NA NA < 0.001
 I vs. II 3.71 1.32–10.41 0.013
 I vs. III 2.06 0.72–5.85 0.177
 I vs. IV 9.60 3.20–28.84 0.001
Progression-free survival (PFS)
Completed resection (no v yes) 0.40 0.22–0.72 0.002
Classification based on PD-L1 expression and CD8+ TILs
 Overall NA NA 0.014
 I vs. II 2.61 1.12–6.09 0.027
 I vs. III 2.15 0.89–5.20 0.090
 I vs. IV 4.99 1.87–13.31 0.001
  1. Note: Multivariate analysis, Cox proportional hazards regression model (based on Wald Forward selection)
  2. Variables were adopted for their prognostic significance by univariate analysis
  3. Subgroups: I (CD8high&PD-L1); II (CD8high&PD-L1+); III (CD8low&PD-L1); IV (CD8low&PD-L1+)