Table 4 CXCR4 and CXCL12 status in primary tumors, regional and distant metastases of cats with mammary carcinoma, stratified accordingly to the molecular subtype of the primary tumor
Primary tumor | Regional metastases | Distant metastases | ||
|---|---|---|---|---|
Luminal A | CXCR4 | |||
Negative | 1/13 (7.7) | 2/4 (50.0) | 2/3 (66.7) | |
Positive | 12/13 (92.3) | 2/4 (50.0) | 1/3 (33.3) | |
CXCL12 | ||||
Negative | 5/13 (38.5) | 0/4 (0.00) | 0/3 (0.00) | |
Positive | 8/13 (61.5) | 4/4 (100) | 3/3 (100) | |
Luminal B | CXCR4 | |||
Negative | 3/31 (9.7) | 5/15 (33.3) | 3/4 (75.0) | |
Positive | 28/31 (90.3) | 10/15 (66.7) | 1/4 (25.0) | |
CXCL12 | ||||
Negative | 8/32 (25.0) | 0/15 (0.00) | 0/4 (0%) | |
Positive | 24/32 (75.0) | 15/15 (100) | 4/4 (100) | |
Luminal B-HER2+/HER2+ | CXCR4 | |||
Negative | 7/31 (22.6) | 2/13 (15.4) | 0/5 (0.0) | |
Positive | 24/31 (77.4) | 11/13 (84.6) | 5/5 (100) | |
CXCL12 | ||||
Negative | 6/30 (20.0) | 2/14 (14.3) | 0/5 (0.0) | |
Positive | 24/30 (80.0) | 12/14 (85.7) | 5/5 (100) | |
Triple negative | CXCR4 | |||
Negative | 9/38 (23.7) | 5/15 (33.3) | 7/13 (53.9) | |
Positive | 29/38 (76.3) | 10/15 (66.7) | 6/13 (46.1) | |
CXCL12 | ||||
Negative | 6/39 (15.4) | 0/15 (0.0) | 0/13 (0.00) | |
Positive | 33/39 (84.6) | 15/15 (100) | 13/13 (100) | |