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Table 3 Factors associated with PFS

From: Correlation between circulating tumour DNA and metabolic tumour burden in metastatic melanoma patients

Factor Variable Univariate analysis Multivariate analysis
p-value HR CI (95%) p-value HR CI (95%)
ctDNA positive/negative 0.009* 6.973 1.612–30.165 0.007* 7.658 1.762–33.283
Age Continuous 0.619 0.992 0.961–1.024 0.558 0.988 0.949–1.029
Sex Male vs. Female 0.419 0.834 0.537–1.295 0.548 1.184 0.682–2.058
ECOG 0–2 0.747 1.127 0.544–2.337 0.526 1.284 0.593–2.781
MTB$ > 34 vs. ≤34 0.018* 5.845 1.356–25.206    
Stage M1a,b vs. M1c 0.035* 1.454 0.218–0.945    
  1. Abbreviations: ctDNA circulating tumour DNA, ECOG Eastern Cooperative Oncology Group, MTB Metabolic Tumour Burden, HR hazard ratio, CI confidence interval. *Statistically significant. $Dichotomised at First Interquartile