Skip to main content

Table 8 Correlation analysis between methylation and protein expression of YAP1 in stratification by various clinical characteristics in Indian breast cancer patients

From: Aberrant Promoter Methylation of YAP Gene and its Subsequent Downregulation in Indian Breast Cancer Patients

Characteristic

Total (N)

YAP1 methylation status

YAP1 expression

p value

Absent

Present

Age (years)

≤50

78 (56.93)

M

50

7

0.046

  

UM

14

7

 

>50

59 (43.07)

M

34

6

0.017

  

UM

10

9

 

Age at menarche

≤12

26 (18.98)

M

17

1

0.215

  

UM

6

2

 

>12

111 (81.02)

M

67

12

0.002

  

UM

18

14

 

Menopausal status

Premenopausal

40 (29.20)

M

23

5

0.677

  

UM

9

3

 

Postmenopausal

97 (70.80)

M

61

8

<0.0007

  

UM

15

13

 

Age at menopause

≤45

33 (34.02)

M

21

0

0.003

  

UM

7

5

 

>45

64 (65.98)

M

40

8

0.016

  

UM

8

8

 

ER status

Positive

81 (59.12)

M

45

9

<0.002

  

UM

13

14

 

Negative

56 (40.88)

M

39

4

0.615

  

UM

11

2

 

PR status

Positive

47 (34.31)

M

30

5

0.205

  

UM

8

4

 

Negative

90 (65.69)

M

54

8

<0.003

  

UM

16

12

 

Her2 status

Positive

66 (48.18)

M

42

6

0.014

  

UM

10

8

 

Negative

71 (51.82)

M

42

7

0.057

  

UM

14

8

 

Molecular subtypes of breast cancer

Luminal A

46 (33.58)

M

25

5

0.036

  

UM

8

8

 

Luminal B

38 (27.74)

M

22

4

0.045

  

UM

6

6

 

Her2-enriched

28 (20.44)

M

20

2

0.191

  

UM

4

2

 

TNBC

25 (18.25)

M

17

2

1

  

UM

6

0

 

Tumor size

≤5

55 (40.15)

M

36

4

0.193

  

UM

11

4

 

>5

82 (59.85)

M

48

9

<0.005

  

UM

13

12

 

Lymph node status

Positive

99 (72.26)

M

61

9

<0.002

  

UM

16

13

 

Negative

38 (27.74)

M

23

4

0.39

  

UM

8

3

 

Clinical stage

I+II

45(32.85)

M

31

3

0.05

  

UM

7

4

 

III+IV

92(67.15)

M

53

10

0.016

  

UM

17

12

 

Histological grade

I+II

95 (69.34)

M

59

9

0.02

  

UM

17

10

 

III

42 (30.66)

M

25

4

0.05

  

UM

7

6

 
  1. p value (Fisher’s Exact Test), Bonferroni significance level p ≤ 0.0025