Table 4 Correlation analysis of YAP1 protein expression levels with the clinical parameters in Indian breast cancer patients
Characteristic | Total (N) | YAP1 absent | YAP1 present | p value |
|---|---|---|---|---|
Age (years) | ||||
≤50 | 78 (56.93) | 64 (82.05) | 14 (17.95) | 0.3 |
>50 | 59 (43.07) | 44 (74.58) | 15 (25.42) | Â |
Age at menarche | ||||
≤12 | 26 (18.98) | 23 (88.46) | 3 (11.54) | 0.258 |
>12 | 111 (81.02) | 85 (76.58) | 26 (23.42) | Â |
Menopausal status | ||||
Premenopausal | 40 (29.20) | 32 (80) | 8 (20) | 1 |
Postmenopausal | 97 (70.80) | 76 (78.35) | 21 (21.65) | Â |
Age at menopause | ||||
≤45 | 33 (34.02) | 28 (84.85) | 5 (15.15) | 0.309 |
>45 | 64 (65.98) | 48 (75) | 16 (25) | Â |
ER status | ||||
Positive | 81 (59.12) | 58 (71.60) | 23 (28.4) | 0.018 |
Negative | 56 (40.88) | 50 (89.29) | 6 (10.71) | Â |
PR status | ||||
Positive | 47 (34.31) | 38 (80.85) | 9 (19.15) | 0.826 |
Negative | 90 (65.69) | 70 (77.78) | 20 (22.22) | Â |
Her2 status | ||||
Positive | 66 (48.18) | 52 (78.79) | 14 (21.21) | 1 |
Negative | 71 (51.82) | 56 (78.87) | 15 (21.13) | Â |
Molecular subtypes of breast cancer | ||||
Luminal A | 46 (33.58) | 33 (71.74) | 13 (28.26) | 0.146 |
Luminal B | 38 (27.74) | 28 (73.68) | 10 (26.32) | Â |
Her2-enriched | 28 (20.44) | 24 (85.71) | 4 (14.29) | Â |
TNBC | 25 (18.25) | 23 (92) | 2 (8) | Â |
Tumor size | ||||
≤5 | 55 (40.15) | 47 (85.45) | 8 (14.55) | 0.139 |
>5 | 82 (59.85) | 61 (74.39) | 21 (25.61) | Â |
Lymph node status | ||||
Positive | 99 (72.26) | 77 (77.78) | 22 (22.22) | 0.816 |
Negative | 38 (27.74) | 31 (81.58) | 7 (18.42) | Â |
Clinical stage | Â | Â | Â | Â |
I+II | 45(32.85) | 38 (84.44) | 7 (15.56) | 0.373 |
III+IV | 92(67.15) | 70 (76.09) | 22 (23.91) | Â |
Histological grade | ||||
I+II | 95 (69.34) | 76 (80) | 19 (20) | 0.653 |
III | 42 (30.66) | 32 (76.19) | 10 (23.81) | Â |