Fatty acid oxidation is associated with proliferation and prognosis in breast and other cancers

Table 5 FAO signature expression is prognostic independent of standard histopathological features in breast cancer

Dataset	Study	n^a	Covariates	Hazard ratio (survival metric)	FDR adjusted p
GSE25066	Hatzis et al.	466	Grade, ER status	1.62 (DRFS)	0.0592
BRCA2116	Nagalla et al.	660	Grade, size, lymph node status	1.5 (DRFS)	0.09
GSE42568	Clarke et al.	104	Grade, size, lymph node status	2.55 (RFS)	0.009
GSE22219	Buffa et al.	216	ER status, size, age, lymph node status	1.91 (DRFS)	0.014
GSE46563	Jonsdottir et al.	94	Grade, ER status, size	5.54 (DRFS)	0.009
GSE20685	Kao et al.	327	Age	1.7 (DRFS)	0.009
TCGA BRCA	TCGA breast cancer	776	ER status	1.61 (RFS)	0.09

^aOf note, the sample sizes in this analysis differ slightly with that presented in Table 3 as there were incomplete clinical information for some patients in certain datasets. DRFS, distant relapse-free survival; RFS, relapse-free survival