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Fig. 5 | BMC Cancer

Fig. 5

From: Comprehensive transcriptomic analysis of heat shock proteins in the molecular subtypes of human breast cancer

Fig. 5

HSPs gene expression heatmap of TCGA BRCA cohorts. Expression patterns of 89 HSP genes in 1033 samples are depicted (central panel, low expression levels in blue and high expression levels in red). By a hierarchical clustering algorithm patients were group into HSP-Clust I (red), HSP-Clust II (green) and HSP-Clust III (orange) (upper dendrogram). Several rows were added to indicate: immunohistochemical status of receptors (ER, PR and HER2), tumour size (T > 2 cm or T < 2 cm), satellite nodules spread (N positive or N negative) and PAM50 classification. We also added three columns indicating HSP corresponding subfamilies, univariate Cox’s regression model coefficients (pink represents positives coefficients (bad prognosis), while light blue are negatives coefficients (good prognosis)) and its corresponding FDR values (black boxes represent FDR value for Cox’s coefficients < 0.05)

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