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Table 3 Univariate and multivariate analyses of prognostic factors associated with cancer-specific survival

From: Preoperative controlling nutritional status (CONUT) score as a predictor of long-term outcome after curative resection followed by adjuvant chemotherapy in stage II-III gastric Cancer

  Univariate analysis Multivariate analysis
  HR (95% CI) P-value HR (95% CI) P-value
Age (years) 0.024 0.421
  < 60 1.00 1.00
  ≥ 60 1.292 (1.035, 1.613) 1.130 (0.839, 1.522)
Sex 0.252  
 Female 1.00  
 Male 0.875 (0.695, 1.100)  
Tumor size (cm) < 0.001 0.997
  < 5 1.00 1.00
  ≥ 5 1.505 (1.204, 1.880) 0.999 (0.737, 1.356)
Tumor location < 0.001 0.027
 Lower third 1.00 1.00
 Upper/Middle third 1.524 (1.209, 1.922) 1.453 (1.044, 2.022)
Histological grade 0.340  
 Well differentiated 1.00  
 Poorly differentiated 1.179 (0.840, 1.655)  
Lauren histotype 0.235  
 Intestinal 1.00  
 Diffuse / Mixed 0.859 (0.669, 1.104)  
LVI < 0.001 0.041
 Absent 1.00 1.00
 Present 1.602 (1.299, 1.977) 1.294 (1.011, 1.657)
pT stage 0. 001  
 pT1/2 1.00  
 pT3/4 2.960 (1.573, 5.571)  
pN stage < 0.001  
 pN0/1 1.00  
 pN2/3 3.743 (2.734, 5.124)  
Dissected lymph nodes 0.118  
  ≤ 29 1.00  
  > 29 1.107 (0.974, 1.258)  
TNM stage < 0.001 < 0.001
 II 1.00 1.00
 III 4.597 (3.218, 6.567) 4.625 (2.883, 7.421)
Operation type 0.015 0.669
 Subtotal 1.00 1.00
 Total/extended 1.340 (1.058, 1.697) 1.083 (0.752, 1.558)
Complications 0.755  
 No 1.00  
 Yes 0.953 (0.701, 1.293)  
Performance status 0.548  
 0 1.00  
 1/2 0.924 (0.716, 1.194)  
BMI (Kg/m2) 0.159  
  < 18.5 1.00  
 18.5≤ 1.173 (0.940, 1.464)  
PNI < 0.001 0.085
  ≥ 45 1.00 1.00
  < 45 1.777 (1.313, 2.404) 1.505 (0.945, 2.396)
Anemia 0.231  
 No 1.00  
 Yes 1.155 (0.912, 1.463)  
CONUT < 0.001 0.017
  ≤ 2 1.00 1.00
  ≥ 3 1.576 (1.255, 1.978) 1.553 (1.080, 2.232)
CEA 0.009 0.269
 Normal 1.00 1.00
 Elevated 1.407 (1.087, 1.822) 1.222 (0.857, 1.742)
CA19–9 0.002 0.033
 Normal 1.00 1.00
 Elevated 1.555 (1.183, 2.042) 1.427 (1.029, 1.979)
CA72–4 0.012 0.476
 Normal 1.00 1.00
 Elevated 1.447 (1.086, 1.927) 1.125 (0.814, 1.555)
  1. Abbreviations: LVI lymphatic vessel infiltration, TNM tumor-node-metastasis staging, BMI body mass index, PNI prognostic nutritional index, CONUT controlling nutritional status, CEA carcinoembryonic antigen, CA carbohydrate antigen