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Table 3 Univariate and multivariate analyses of prognostic factors associated with cancer-specific survival

From: Preoperative controlling nutritional status (CONUT) score as a predictor of long-term outcome after curative resection followed by adjuvant chemotherapy in stage II-III gastric Cancer

 

Univariate analysis

Multivariate analysis

 

HR (95% CI) P-value

HR (95% CI) P-value

Age (years)

0.024

0.421

  < 60

1.00

1.00

  ≥ 60

1.292 (1.035, 1.613)

1.130 (0.839, 1.522)

Sex

0.252

 

 Female

1.00

 

 Male

0.875 (0.695, 1.100)

 

Tumor size (cm)

< 0.001

0.997

  < 5

1.00

1.00

  ≥ 5

1.505 (1.204, 1.880)

0.999 (0.737, 1.356)

Tumor location

< 0.001

0.027

 Lower third

1.00

1.00

 Upper/Middle third

1.524 (1.209, 1.922)

1.453 (1.044, 2.022)

Histological grade

0.340

 

 Well differentiated

1.00

 

 Poorly differentiated

1.179 (0.840, 1.655)

 

Lauren histotype

0.235

 

 Intestinal

1.00

 

 Diffuse / Mixed

0.859 (0.669, 1.104)

 

LVI

< 0.001

0.041

 Absent

1.00

1.00

 Present

1.602 (1.299, 1.977)

1.294 (1.011, 1.657)

pT stage

0. 001

 

 pT1/2

1.00

 

 pT3/4

2.960 (1.573, 5.571)

 

pN stage

< 0.001

 

 pN0/1

1.00

 

 pN2/3

3.743 (2.734, 5.124)

 

Dissected lymph nodes

0.118

 

  ≤ 29

1.00

 

  > 29

1.107 (0.974, 1.258)

 

TNM stage

< 0.001

< 0.001

 II

1.00

1.00

 III

4.597 (3.218, 6.567)

4.625 (2.883, 7.421)

Operation type

0.015

0.669

 Subtotal

1.00

1.00

 Total/extended

1.340 (1.058, 1.697)

1.083 (0.752, 1.558)

Complications

0.755

 

 No

1.00

 

 Yes

0.953 (0.701, 1.293)

 

Performance status

0.548

 

 0

1.00

 

 1/2

0.924 (0.716, 1.194)

 

BMI (Kg/m2)

0.159

 

  < 18.5

1.00

 

 18.5≤

1.173 (0.940, 1.464)

 

PNI

< 0.001

0.085

  ≥ 45

1.00

1.00

  < 45

1.777 (1.313, 2.404)

1.505 (0.945, 2.396)

Anemia

0.231

 

 No

1.00

 

 Yes

1.155 (0.912, 1.463)

 

CONUT

< 0.001

0.017

  ≤ 2

1.00

1.00

  ≥ 3

1.576 (1.255, 1.978)

1.553 (1.080, 2.232)

CEA

0.009

0.269

 Normal

1.00

1.00

 Elevated

1.407 (1.087, 1.822)

1.222 (0.857, 1.742)

CA19–9

0.002

0.033

 Normal

1.00

1.00

 Elevated

1.555 (1.183, 2.042)

1.427 (1.029, 1.979)

CA72–4

0.012

0.476

 Normal

1.00

1.00

 Elevated

1.447 (1.086, 1.927)

1.125 (0.814, 1.555)

  1. Abbreviations: LVI lymphatic vessel infiltration, TNM tumor-node-metastasis staging, BMI body mass index, PNI prognostic nutritional index, CONUT controlling nutritional status, CEA carcinoembryonic antigen, CA carbohydrate antigen