| Univariate analysis | Multivariate analysis |
---|---|---|
 | HR (95% CI) P-value | HR (95% CI) P-value |
Age (years) | 0.024 | 0.421 |
  < 60 | 1.00 | 1.00 |
  ≥ 60 | 1.292 (1.035, 1.613) | 1.130 (0.839, 1.522) |
Sex | 0.252 | Â |
 Female | 1.00 |  |
 Male | 0.875 (0.695, 1.100) |  |
Tumor size (cm) | < 0.001 | 0.997 |
  < 5 | 1.00 | 1.00 |
  ≥ 5 | 1.505 (1.204, 1.880) | 0.999 (0.737, 1.356) |
Tumor location | < 0.001 | 0.027 |
 Lower third | 1.00 | 1.00 |
 Upper/Middle third | 1.524 (1.209, 1.922) | 1.453 (1.044, 2.022) |
Histological grade | 0.340 | Â |
 Well differentiated | 1.00 |  |
 Poorly differentiated | 1.179 (0.840, 1.655) |  |
Lauren histotype | 0.235 | Â |
 Intestinal | 1.00 |  |
 Diffuse / Mixed | 0.859 (0.669, 1.104) |  |
LVI | < 0.001 | 0.041 |
 Absent | 1.00 | 1.00 |
 Present | 1.602 (1.299, 1.977) | 1.294 (1.011, 1.657) |
pT stage | 0. 001 | Â |
 pT1/2 | 1.00 |  |
 pT3/4 | 2.960 (1.573, 5.571) |  |
pN stage | < 0.001 |  |
 pN0/1 | 1.00 |  |
 pN2/3 | 3.743 (2.734, 5.124) |  |
Dissected lymph nodes | 0.118 | Â |
  ≤ 29 | 1.00 |  |
  > 29 | 1.107 (0.974, 1.258) |  |
TNM stage | < 0.001 | < 0.001 |
 II | 1.00 | 1.00 |
 III | 4.597 (3.218, 6.567) | 4.625 (2.883, 7.421) |
Operation type | 0.015 | 0.669 |
 Subtotal | 1.00 | 1.00 |
 Total/extended | 1.340 (1.058, 1.697) | 1.083 (0.752, 1.558) |
Complications | 0.755 | Â |
 No | 1.00 |  |
 Yes | 0.953 (0.701, 1.293) |  |
Performance status | 0.548 | Â |
 0 | 1.00 |  |
 1/2 | 0.924 (0.716, 1.194) |  |
BMI (Kg/m2) | 0.159 | Â |
  < 18.5 | 1.00 |  |
 18.5≤ | 1.173 (0.940, 1.464) |  |
PNI | < 0.001 | 0.085 |
  ≥ 45 | 1.00 | 1.00 |
  < 45 | 1.777 (1.313, 2.404) | 1.505 (0.945, 2.396) |
Anemia | 0.231 | Â |
 No | 1.00 |  |
 Yes | 1.155 (0.912, 1.463) |  |
CONUT | < 0.001 | 0.017 |
  ≤ 2 | 1.00 | 1.00 |
  ≥ 3 | 1.576 (1.255, 1.978) | 1.553 (1.080, 2.232) |
CEA | 0.009 | 0.269 |
 Normal | 1.00 | 1.00 |
 Elevated | 1.407 (1.087, 1.822) | 1.222 (0.857, 1.742) |
CA19–9 | 0.002 | 0.033 |
 Normal | 1.00 | 1.00 |
 Elevated | 1.555 (1.183, 2.042) | 1.427 (1.029, 1.979) |
CA72–4 | 0.012 | 0.476 |
 Normal | 1.00 | 1.00 |
 Elevated | 1.447 (1.086, 1.927) | 1.125 (0.814, 1.555) |