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Table 2 Dosing, dose reductions and sequencing of nal-IRI + 5-FU/LV

From: Nanoliposomal irinotecan with fluorouracil for the treatment of advanced pancreatic cancer, a single institution experience

 

N = 56 (%)

Starting nal-IRI dose (mg/m2)

  < 50

23 (41)

 55

9 (16)

 60

7 (13)

 70

17 (30)

Dose reductions (#)

 0

38 (68)

 1

15 (27)

 2

3 (5)

Treatment sequencing

 FOLF (IRIN) OX ← → (nab-P) + Gem → nal-IRI + 5-FU/LV

26 (46)

 nab-P + Gem → nal-IRI + 5-FU/LV

25 (45)

 nab-P + Gem → Gem/Cap → nal-IRI + 5-FU/LV

3 (5)

 other

2 (4)