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Table 1 Clinicopathological characteristics of all individuals in the training stage and relationships with circulating miRNAs in the plasma

From: Droplet digital PCR-based circulating microRNA detection serve as a promising diagnostic method for gastric cancer

Characteristics   miR-21 miR-93 miR-106a miR-106b
Total (%) Mean ± SD P value Mean ± SD P value Mean ± SD P value Mean ± SD P value
GC patients
 Gender
  Male 51(50.5) 300.2 ± 127.7 0.437 206.3 ± 87.8 0.318 41.3 ± 18.7 0.404 26.3 ± 11.8 0.353
  Female 50(49.5) 300.8 ± 187.5 188.6 ± 70.5 37.7 ± 16.1 24.0 ± 11.1
 Age (years)
  ≥ 60 45(44.6) 303.4 ± 187.7 0.562 203.5 ± 87.0 0.696 36.9 ± 16.4 0.159 22.7 ± 11.2 0.019*
  < 60 56(55.4) 298.1 ± 133.9 192.7 ± 73.9 41.6 ± 18.2 27.1 ± 11.4
 Tumor size (cm)
  ≥ 5 29(28.7) 358.8 ± 183.5 0.029* 198.9 ± 63.9 0.684 43.0 ± 14.9 0.071 26.5 ± 8.8 0.165
  < 5 72(71.3) 277.0 ± 143.2 196.9 ± 85.8 38.1 ± 18.3 24.6 ± 12.4
 Differentiation
  Well 16(15.8) 296.4 ± 158.4 0.078 200.9 ± 86.1 0.976 39.7 ± 17.4 0.601 26.7 ± 13.1 0.891
  Moderate 35(34.7) 353.8 ± 187.5 196.0 ± 69.2 37.9 ± 18.8 25.4 ± 12.1
  Poor 50(49.5) 264.5 ± 127.9 197.5 ± 86.0 40.6 ± 16.1 24.5 ± 10.6
 Lymph node metastasis
  Positive 66(65.3) 329.1 ± 172.3 0.014* 210.8 ± 80.7 0.019* 40.1 ± 16.7 0.438 27.9 ± 11.2 0.0002*
  Negative 35(34.7) 246.5 ± 115.4 172.4 ± 72.7 38.5 ± 19.0 20.0 ± 10.1
 Distant metastasis
  Positive 18(21.7) 304.1 ± 122.3 0.435 218.8 ± 91.4 0.371 41.4 ± 15.1 0.297 25.6 ± 10.5 0.572
  Negative 83(78.3) 299.7 ± 166.8 192.9 ± 76.9 39.1 ± 18.0 25.1 ± 11.7
 TNM stage
  I 28(27.7) 234 ± 119.7 0.0062* 175.8 ± 78.3 0.0571 37 ± 19.4 0.7371 19.3 ± 9 0.0016*
  II 13(12.9) 241.8 ± 101.5 182.5 ± 84.6 40.9 ± 15.6 21.7 ± 10.9
  III 36(35.6) 329.5 ± 173.2 195.9 ± 66.1 39.2 ± 17.7 27.8 ± 11.1
  IV 24(23.8) 366.2 ± 171.2 233.4 ± 89.7 42.3 ± 16.4 29.9 ± 12
Healthy voluteers
 Gender
  Male 26(56.5) 142.8 ± 62.8 0.475 128 ± 56.6 0.784 29.2 ± 17.1 0.33 17.4 ± 10.6 0.123
  Female 20(43.5) 172 ± 101.1 133.3 ± 63.2 25.1 ± 14.7 13.1 ± 7.3
 Age (years)
  ≥ 60 18(39.1) 158.2 ± 67.2 0.632 146.7 ± 66.8 0.249 28.4 ± 21.4 0.486 16.4 ± 12.2 0.726
  < 60 28(60.9) 153.7 ± 91.4 119.8 ± 51.8 26.8 ± 11.9 15 ± 7.4
  1. *means P-value< 0.05