Table 1 Clinicopathological characteristics of all individuals in the training stage and relationships with circulating miRNAs in the plasma
Characteristics | Â | miR-21 | miR-93 | miR-106a | miR-106b | ||||
|---|---|---|---|---|---|---|---|---|---|
Total (%) | Mean ± SD | P value | Mean ± SD | P value | Mean ± SD | P value | Mean ± SD | P value | |
GC patients | |||||||||
 Gender | |||||||||
  Male | 51(50.5) | 300.2 ± 127.7 | 0.437 | 206.3 ± 87.8 | 0.318 | 41.3 ± 18.7 | 0.404 | 26.3 ± 11.8 | 0.353 |
  Female | 50(49.5) | 300.8 ± 187.5 | 188.6 ± 70.5 | 37.7 ± 16.1 | 24.0 ± 11.1 | ||||
 Age (years) | |||||||||
  ≥ 60 | 45(44.6) | 303.4 ± 187.7 | 0.562 | 203.5 ± 87.0 | 0.696 | 36.9 ± 16.4 | 0.159 | 22.7 ± 11.2 | 0.019* |
  < 60 | 56(55.4) | 298.1 ± 133.9 | 192.7 ± 73.9 | 41.6 ± 18.2 | 27.1 ± 11.4 | ||||
 Tumor size (cm) | |||||||||
  ≥ 5 | 29(28.7) | 358.8 ± 183.5 | 0.029* | 198.9 ± 63.9 | 0.684 | 43.0 ± 14.9 | 0.071 | 26.5 ± 8.8 | 0.165 |
  < 5 | 72(71.3) | 277.0 ± 143.2 | 196.9 ± 85.8 | 38.1 ± 18.3 | 24.6 ± 12.4 | ||||
 Differentiation | |||||||||
  Well | 16(15.8) | 296.4 ± 158.4 | 0.078 | 200.9 ± 86.1 | 0.976 | 39.7 ± 17.4 | 0.601 | 26.7 ± 13.1 | 0.891 |
  Moderate | 35(34.7) | 353.8 ± 187.5 | 196.0 ± 69.2 | 37.9 ± 18.8 | 25.4 ± 12.1 | ||||
  Poor | 50(49.5) | 264.5 ± 127.9 | 197.5 ± 86.0 | 40.6 ± 16.1 | 24.5 ± 10.6 | ||||
 Lymph node metastasis | |||||||||
  Positive | 66(65.3) | 329.1 ± 172.3 | 0.014* | 210.8 ± 80.7 | 0.019* | 40.1 ± 16.7 | 0.438 | 27.9 ± 11.2 | 0.0002* |
  Negative | 35(34.7) | 246.5 ± 115.4 | 172.4 ± 72.7 | 38.5 ± 19.0 | 20.0 ± 10.1 | ||||
 Distant metastasis | |||||||||
  Positive | 18(21.7) | 304.1 ± 122.3 | 0.435 | 218.8 ± 91.4 | 0.371 | 41.4 ± 15.1 | 0.297 | 25.6 ± 10.5 | 0.572 |
  Negative | 83(78.3) | 299.7 ± 166.8 | 192.9 ± 76.9 | 39.1 ± 18.0 | 25.1 ± 11.7 | ||||
 TNM stage | |||||||||
  I | 28(27.7) | 234 ± 119.7 | 0.0062* | 175.8 ± 78.3 | 0.0571 | 37 ± 19.4 | 0.7371 | 19.3 ± 9 | 0.0016* |
  II | 13(12.9) | 241.8 ± 101.5 | 182.5 ± 84.6 | 40.9 ± 15.6 | 21.7 ± 10.9 | ||||
  III | 36(35.6) | 329.5 ± 173.2 | 195.9 ± 66.1 | 39.2 ± 17.7 | 27.8 ± 11.1 | ||||
  IV | 24(23.8) | 366.2 ± 171.2 | 233.4 ± 89.7 | 42.3 ± 16.4 | 29.9 ± 12 | ||||
Healthy voluteers | |||||||||
 Gender | |||||||||
  Male | 26(56.5) | 142.8 ± 62.8 | 0.475 | 128 ± 56.6 | 0.784 | 29.2 ± 17.1 | 0.33 | 17.4 ± 10.6 | 0.123 |
  Female | 20(43.5) | 172 ± 101.1 | 133.3 ± 63.2 | 25.1 ± 14.7 | 13.1 ± 7.3 | ||||
 Age (years) | |||||||||
  ≥ 60 | 18(39.1) | 158.2 ± 67.2 | 0.632 | 146.7 ± 66.8 | 0.249 | 28.4 ± 21.4 | 0.486 | 16.4 ± 12.2 | 0.726 |
  < 60 | 28(60.9) | 153.7 ± 91.4 | 119.8 ± 51.8 | 26.8 ± 11.9 | 15 ± 7.4 | ||||