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Fig. 3 | BMC Cancer

Fig. 3

From: Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways

Fig. 3

Inhibition of leucine uptake alone does not recapitulate the effects of BenSer. Leucine (a) and glutamine (b) uptake over 15 min were measured in MCF-7, HCC1806 and MDA-MB-231 (MDA-231) cells in the presence or absence of 10 mM BCH. Relative cell viability measured by MTT assay in MCF-7 (c), HCC1806 (d), and MDA-MB-231 (e) cells cultured for 3 days in the presence or absence of 10 mM BCH. Data represent mean ± SEM of at least three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; unpaired student’s t-test (a-b), 2-way ANOVA (c-e)

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