Fig. 7

The mechanism of Nm23-H1 participating in multiple steps of DSBR pathway. Nm23-H1 involved in two pathways, which was cell-cycle checkpoint signaling pathway (ATM, Chk2 and p53 phosphorylated signaling pathway) and DNA repair pathway (interaction with Ku80). Moreover, Nm23-H1 also interacted with MRN complex. MRN complex functioned as the recognition and stabilization of DSBs and was the part of the DSB-sensing machinery. Thus the interaction of Nm23-H1 with MRN complex may promote the signaling of above two pathways