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Table 3 Overview over TP53 mutations observed in patients

From: High expression of the p53 isoform γ is associated with reduced progression-free survival in uterine serous carcinoma

Patient ID FIGO 2009 tumor stage Mutationa Amino acid change Effect Progression free survival (months)
1 1c 7577120C > T R273H missensec 29
2 4b 7577097C > T D281N missenseb 0
3 4b 7577538C > T R248Q missensec 0
4 1b 7577581A > G Y234H missenseb 14
5 3c 7,578,394 T > A H179L missenseb 7
6 2b 7577539G > A R248W missensec 1
7 3c 7578239C > A E204 a nonsenseb 3
8 1c 7577120C > T R273H missensec 14
9 1a 7577573G > T Y236 a nonsenseb 10
7578211C > A R213L missenseb
10 3a 7,577,580 T > C Y234C missenseb 5
11 4b 7577539G > A R248W missensec 58
12 1c 7577153C > A G262 V missenseb 96
13 3c 7577538C > T R248Q missensec 25
14 3c 7578508C > T C141Y missenseb 11
15 1c 7,578,442 T > C Y163C missenseb 11
16 3c 7578406C > T R175H missensec 2
17 4b 7577586A > T I232N missenseb 0
18 3c 7577538C > T R248Q missensec 2
19 1a 7578406C > T R175H missensec 19
21 2a 7579556ATCAA   frameshift 1
23 1b 7577535C > G R249T missenseb 15
25 4a 7578272G > A H193Y missenseb 0
26 3c 7577121G > A R273C missenseb 0
31 3c 7577569TGT   non-frameshift deletion 11
32 3c 7,578,190 T > C Y220C missenseb 0
34 1a 7577141C > T G266E missenseb 11
35 3a 7577130A > G F270 L missenseb 15
7577132C > T S269 N partially functionalb
  1. aCoordinates; GRCh37
  2. bMutation has been reported earlier in the IARC archive [33]
  3. c Hot-spot mutation region