Fig. 1

The p53 protein. a Structure of the human TP53 gene comprising 11 exons. P1 = proximal promoter encoding full-length p53, P2 = internal promoter resulting in Δ133p53 product. Alternative splicing sites (^). b Illustrates the exon composition of relevant p53 isoforms. Abbrevations: Transactivation domain (TAD), DNA binding domain (DBD), C-terminal oligomerization domain (OD)