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Table 5 Multivariable Cox regression analysis of disease-specific survival for colorectal cancer patients

From: Serum MMP-8 and TIMP-1 predict prognosis in colorectal cancer

  Hazard ratio 95% CI P-value
Age, years
  < =65 1.00   
  > 65 1.86 1.14–3.03 0.013
Dukes classification
 A 1.00   
 B 1.87 0.504–6.93 0.350
 C 8.63 2.64–28.2 < 0.001
 D 15.1 4.43–51.6 < 0.001
MMP-8/TIMP-1 ratio
 Low 1.00   
 High 1.72 0.979–3.02 0.059
MMP-9/TIMP-1 ratio
 Low 1.00   
 High 0.573 0.335–0.980 0.042
  1. Abbreviations: MMP matrix metalloproteinase, TIMP-1 tissue inhibitor of metalloproteinases-1, CI confidence interval