Skip to main content

Table 4 Univariable Cox regression analysis of disease-specific survival for colorectal cancer patients

From: Serum MMP-8 and TIMP-1 predict prognosis in colorectal cancer

  Hazard ratio 95% CI P-value
Age, years
  < =65 1.00   
  > 65 1.44 0.98–2.10 0.062
Gender
 Male 1.00   
 Female 1.06 0.73–1.54 0.772
Dukes classification
 A 1.00   
 B 3.33 0.96–11.5 0.057
 C 11.0 3.45–35.3 < 0.001
 D 29.3 9.05–95.1 < 0.001
pT stage
 pT1 1.00   
 pT2 1.62 0.21–12.8 0.648
 pT3 6.33 0.88–45.5 0.067
 pT4 9.89 1.31–75.0 0.067
pN stage
 pN0 1.00   
 pN1 3.77 2.33–6.09 < 0.001
 pN2 5.16 3.15–8.50 < 0.001
pM stage
 pM0 1.00   
 pM1 5.31 3.55–7.93 < 0.001
Grade
 I 1.00   
 II 1.38 0.60–3.17 0.445
 III 1.07 0.36–3.18 0.906
 IV 2.16 0.78–5.93 0.137
Side
 Right 1.00   
 Left 1.45 0.92–2.28 0.107
Location
 Colon 1.00   
 Rectum 1.16 0.79–1.69 0.453
Histologic type
 Adeno 1.00   
 Mucinous 0.95 0.46–1.95 0.888
MMP-8 concentration
 Low 1.00   
 High 1.72 1.17–2.52 0.005
MMP-9 concentration
 Low 1.00   
 High 0.89 0.61–1.31 0.564
TIMP-1 concentration
 Low 1.00   
 High 1.80 1.23–2.64 0.002
MMP-8/TIMP-1 ratio
 Low 1.00   
 High 1.48 1.01–2.16 0.045
MMP-9/TIMP-1 ratio
 Low 1.00   
 High 0.65 0.45–0.96 0.027
CRP (mg/l)
  < =30 1.00   
  > 30 1.75 1.09–2.82 0.021
  1. Abbreviations: MMP matrix metalloproteinase, TIMP-1 tissue inhibitor of metalloproteinases-1, CI confidence interval