Table 4 Univariable Cox regression analysis of disease-specific survival for colorectal cancer patients
From: Serum MMP-8 and TIMP-1 predict prognosis in colorectal cancer
Hazard ratio | 95% CI | P-value | |
|---|---|---|---|
Age, years | |||
< =65 | 1.00 | ||
> 65 | 1.44 | 0.98–2.10 | 0.062 |
Gender | |||
Male | 1.00 | ||
Female | 1.06 | 0.73–1.54 | 0.772 |
Dukes classification | |||
A | 1.00 | ||
B | 3.33 | 0.96–11.5 | 0.057 |
C | 11.0 | 3.45–35.3 | < 0.001 |
D | 29.3 | 9.05–95.1 | < 0.001 |
pT stage | |||
pT1 | 1.00 | ||
pT2 | 1.62 | 0.21–12.8 | 0.648 |
pT3 | 6.33 | 0.88–45.5 | 0.067 |
pT4 | 9.89 | 1.31–75.0 | 0.067 |
pN stage | |||
pN0 | 1.00 | ||
pN1 | 3.77 | 2.33–6.09 | < 0.001 |
pN2 | 5.16 | 3.15–8.50 | < 0.001 |
pM stage | |||
pM0 | 1.00 | ||
pM1 | 5.31 | 3.55–7.93 | < 0.001 |
Grade | |||
I | 1.00 | ||
II | 1.38 | 0.60–3.17 | 0.445 |
III | 1.07 | 0.36–3.18 | 0.906 |
IV | 2.16 | 0.78–5.93 | 0.137 |
Side | |||
Right | 1.00 | ||
Left | 1.45 | 0.92–2.28 | 0.107 |
Location | |||
Colon | 1.00 | ||
Rectum | 1.16 | 0.79–1.69 | 0.453 |
Histologic type | |||
Adeno | 1.00 | ||
Mucinous | 0.95 | 0.46–1.95 | 0.888 |
MMP-8 concentration | |||
Low | 1.00 | ||
High | 1.72 | 1.17–2.52 | 0.005 |
MMP-9 concentration | |||
Low | 1.00 | ||
High | 0.89 | 0.61–1.31 | 0.564 |
TIMP-1 concentration | |||
Low | 1.00 | ||
High | 1.80 | 1.23–2.64 | 0.002 |
MMP-8/TIMP-1 ratio | |||
Low | 1.00 | ||
High | 1.48 | 1.01–2.16 | 0.045 |
MMP-9/TIMP-1 ratio | |||
Low | 1.00 | ||
High | 0.65 | 0.45–0.96 | 0.027 |
CRP (mg/l) | |||
< =30 | 1.00 | ||
> 30 | 1.75 | 1.09–2.82 | 0.021 |