Table 1 Categoly of genes down-regulated and up-regulated in the HPI cell commonly by the treatment with brusatol and by the treatment with siRNA for Nrf2
From: Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells
Category of gene function | Corresponding GO numbera | Number of genes commonly down-regulated (less than 0.5 fold) | Number of genes commonly up-regulated (more than 2 fold) |
|---|---|---|---|
Lipid metabolism | GO:0006629, GO:0016042, GO:0030497 | 10 | 2 |
Cholesterol metabolism | GO:0006695, GO:0008203, GO:0016125 | 6 | 1 |
Glutamine/glutamate metabolism | GO:0006536, GO:0006542, GO:0006749 | 5 | 0 |
Other metabolisms | GO:0008152, GO:0005975 | 12 | 4 |
Oxidation reduction | GO:0055114, GO:0045454, GO:0006979 | 11 | 6 |
Inflammatory/immune response | GO:0006954, GO:0006955 | 3 | 4 |
Transcription | GO:0006810, GO:0015031 | 5 | 30 |
Signal transduction | GO:0007165, | 6 | 10 |
Translation | GO:0006412 | 4 | 2 |
Protein/amino acids modification | GO:0006468, GO:0006470, GO:0006486, GO:0006493, GO:0006464 | 6 | 11 |
Transport | GO:0006810, GO:0015031 | 7 | 4 |
Biologiacal process | GO:0008150 | 2 | 5 |
Cell proliferation/growth | GO:0008285, GO:0008283, O:0007049, GO:0001558 | 5 | 14 |
Apoptosis | GO:0006917, GO:0042981, GO:0006917, GO:0043065 | 3 | 7 |
Cell adhesion | GO:0007155 | 3 | 6 |
Multicellular organismal development | GO:0007275 | 3 | 9 |
Other functions | Â | 12 | 25 |
Unknouwn functions | Â | 21 | 54 |
Totalb | Â | 97 | 163 |