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Table 1 Categoly of genes down-regulated and up-regulated in the HPI cell commonly by the treatment with brusatol and by the treatment with siRNA for Nrf2

From: Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells

Category of gene function Corresponding GO numbera Number of genes commonly down-regulated (less than 0.5 fold) Number of genes commonly up-regulated (more than 2 fold)
Lipid metabolism GO:0006629, GO:0016042, GO:0030497 10 2
Cholesterol metabolism GO:0006695, GO:0008203, GO:0016125 6 1
Glutamine/glutamate metabolism GO:0006536, GO:0006542, GO:0006749 5 0
Other metabolisms GO:0008152, GO:0005975 12 4
Oxidation reduction GO:0055114, GO:0045454, GO:0006979 11 6
Inflammatory/immune response GO:0006954, GO:0006955 3 4
Transcription GO:0006810, GO:0015031 5 30
Signal transduction GO:0007165, 6 10
Translation GO:0006412 4 2
Protein/amino acids modification GO:0006468, GO:0006470, GO:0006486, GO:0006493, GO:0006464 6 11
Transport GO:0006810, GO:0015031 7 4
Biologiacal process GO:0008150 2 5
Cell proliferation/growth GO:0008285, GO:0008283, O:0007049, GO:0001558 5 14
Apoptosis GO:0006917, GO:0042981, GO:0006917, GO:0043065 3 7
Cell adhesion GO:0007155 3 6
Multicellular organismal development GO:0007275 3 9
Other functions   12 25
Unknouwn functions   21 54
Totalb   97 163
  1. agene ontology (GO) number based on Gene Ontology Consortium (http://www.geneontology.org/) bsome genes were overlapped as to category