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Fig. 4 | BMC Cancer

Fig. 4

From: TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association

Fig. 4

Fibroblasts and TGF-β signaling enhance coverage of endothelial cells by pericytes in tumor blood microvessels. a Blood microvessels in tumor sections were stained for CD31 (endothelial cells, Red) and NG2 (pericytes, Brown). Images tumor xenograft sections of carcinoma MDA-MB-231 cells, empty-vector control (EGFP), dnTGFBR1, or constitutively-active TGFBR1 (caTGFBR1), alone and in combination with fibroblasts, × 400 magnification, bar size 20 μm. b Enlargements of the highlighted areas, bar size 20 μm. c Quantification of blood vessels (CD31) associated with pericytes (NG2) in tumor tissues; 3 tumors/group, 3 sections/tumor; **, P < 0.01. d Quantification of pericytes (NG2) in tumor sections that are not associated with endothelium (CD31); 3 tumors/group, 3 sections/tumor; **, P < 0.01

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