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Fig. 3 | BMC Cancer

Fig. 3

From: TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association

Fig. 3

TGF-β signaling increases amounts of tumor-associated fibroblasts. a, b, d Detection of fibroblasts with antibodies to smooth-muscle actin SMA (a-b) and prolyl 4-hydroxylase rPH (d), a marker of rat fibroblasts, in tumor xenograft sections of carcinoma MDA-MB-231 cells: empty-vector control (EGFP), dnTGFBR1 (dnTBR1), or constitutively-active TGFBR1 (caTBR1), alone or in combination with fibroblasts. Images are taken at × 200 magnification, bar size, 50 μm. Panels in (b) show enlargements of marked areas in (a), bar size 25 μm. c Quantification of SMA-positive cells using images taken at × 200 magnification EGFP (6 tumors/group; field images n = 15, 17); dnTGFBR1 (3 tumors/group, n = 9, 8); caTGFBR1 (5 tumors/group, n = 14, 16). *, P < 0.05; **, P < 0.01; ***, P < 0.001

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