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Table 3 Design quality of included trials

From: Thoracic injection of low-dose interleukin-2 as an adjuvant therapy improves the control of the malignant pleural effusions: a systematic review and meta-analysis base on Chinese patients

Study Region Sequence generation Allocation concealment Blind Outcome data Selective outcome reporting Other sources of bias ITT Risk of bias
Changjie H 2001 [15] Single center Random number table Unclear Unclear Yes No Unclear Yes Unclear risk of bias
Xiuzhi Y 2001 [16] Single center Random number table Unclear Unclear Yes No Unclear Yes Unclear risk of bias
Zhuo S 2004 [17] Single center Random number table Unclear Unclear Yes No Unclear Yes Unclear risk of bias
Junyan W 2005 [18] Single center Random number table Unclear Unclear Yes No Unclear Yes Unclear risk of bias
Haiying X 2009 [19] Single center Random number table Unclear Unclear Yes No Unclear Yes Unclear risk of bias
Xiaoxia H 2009 [20] Single center Random number table Unclear Unclear Yes No Unclear Yes Unclear risk of bias
Lizheng C 2009 [21] Single center Random number table Unclear Unclear Yes No Unclear Yes Unclear risk of bias
Jinguang C 2009 [22] Single center Random number table Unclear Unclear Yes No Unclear Yes Unclear risk of bias
Junfeng W 2010 [23] Single center Random number table Unclear Unclear Yes No Unclear Yes Unclear risk of bias
Jingping Z 2010 [24] Single center Random number table Unclear Unclear Yes No Unclear Yes Unclear risk of bias
Cheng X 2010 [25] Single center Random number table Unclear Unclear Yes No Unclear Yes Unclear risk of bias
Fang S 2011 [26] Single center Random number table Unclear Unclear Yes No Unclear Yes Unclear risk of bias
Xueling L 2011 [27] Single center Random number table Unclear Unclear Yes No Unclear Yes Unclear risk of bias
Yan Q 2011 [28] Single center Random number table Unclear Unclear Yes No Unclear Yes Unclear risk of bias
Li J 2013 [29] Single center Random number table Unclear Unclear Yes No Unclear Yes Unclear risk of bias
Lijie H 2014 [30] Single center Random number table Unclear Unclear Yes No Unclear Yes Unclear risk of bias
Miao H 2016 [31] Single center Random number table Unclear Unclear Yes No Unclear Yes Unclear risk of bias
Baohua Y 2017 [32] Single center Random number table Unclear Clear Yes No Clear Yes Low risk of bias
  1. ITT intention-to-treat