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Fig. 2 | BMC Cancer

Fig. 2

From: WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage

Fig. 2

WDR5 depletion or disruption of the COMPASS complex limits cell proliferation or viability in colon cancer cells. a and b Cell viability in a panel of colon cancer cells as compared to HCECs following RNAi-mediated depletion of WDR5. Viability was measured by CellTiter-Glo® (a) and alamarBlue® (b) assays 72 h after transfection. c Cell viability in a panel of colon cancer cells as compared to HCECs following 72-h treatment with 10 μM OICR-9429 as measured by alamarBlue®. Data are shown as relative light units or relative fluorescent intensity ± SD. ** p < 0.01 *** p < 0.001 **** p < 0.0001

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