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Table 2 Disease–specific survival in patients with high-grade salivary gland cancers (n = 124)

From: Treatment outcomes in metastatic and localized high-grade salivary gland cancer: high chance of cure with surgery and post-operative radiation in T1–2 N0 high-grade salivary gland cancer

Factors (Number) Univariate model Multivariate model #1 Multivariate model #2
HR 95% CI P HR 95% CI P HR 95% CI P
 Age (years) 1.021 0.994–1.049 0.135       
 Gender (Male/Female) (95/29) 1.446 0.636–3.290 0.379       
 Primary site
  Parotid gland (84) 1 (Ref.)         
  Non-parotid gland (40) 1.246 0.640–2.427 0.518       
 TNM categories
  T3–4/T1–2 (60/64) 1.880 0.980–3.608 0.058 0.824 0.412–1.648 0.584 1.145 0.593–2.212 0.687
  N1–3/N0 (61/63) 5.573 2.651–11.713 < 0.001 8.669 3.787–19.842 < 0.001 5.632 2.638–12.027 < 0.001
  M1/M0 (15/109) 4.550 2.139–9.680 < 0.001     4.591 2.100–10.035 < 0.001
Pathological diagnosis
  Salivary duct carcinoma (74) 1 (Ref.)         
  Squamous cell carcinoma, primary (13) 1.271 0.480–3.368 0.629       
  Adenoid cystic carcinoma, solid type (12) 1.422 0.537–3.766 0.479       
  Mucoepidermoid carcinoma, high-grade (9) 1.094 0.326–3.673 0.885       
  Adenocarcinoma, high-grade (6) 0.386 0.052–2.870 0.352       
  Others* (10) 1.681 0.501–5.642 0.440       
 Treatment modalities
  Surgery (13) 1 (Ref)    1 (Ref.)      
  Surgery + radiation (62) 1.247 0.372–4.182 0.721 0.761 0.216–2.678 0.671    
  Surgery + radiation + chemotherapy (28) 0.418 0.084–2.075 0.286 0.134 0.025–0.709 0.018    
  Others (21) 4.589 1.281–16.434 0.019 2.786 0.731–10.617 0.133    
  1. M1 status was significantly associated with the application of the so-called other treatment modalities (initial non-surgical, chemotherapy or palliative treatments); thus, we built two separate multivariate models using independent variables
  2. Abbreviation:
  3. HR Hazard ratio, CI Confidence interval
  4. Others*: Atypical high-grade carcinoma, high-grade carcino-sarcoma, poorly differentiated carcinoma
  5. Others: Initial non-surgical local treatment (radiation or chemoradiation), chemotherapy or palliative treatment