Fig. 1
From: Pancreatic cancer as a sentinel for hereditary cancer predisposition
Flow chart of methods. Includes the weighting assigned to filtered sequence variants. In the second set of unselected pancreatic cancer cases 16 cases failed testing with the custom 59-gene panel and/or declined testing with the Invitae hciPancreasCA panel. MAF = minor allele frequency; HiP-VUS = high probability of pathogenicity variant of uncertain significance; MMR – mismatch repair; Prior_P = sequence analysis-based prior probability of pathogenicity