Table 5 IC50 values for used chemotherapeutics calculated by Calcusyn for transfected cell lines
From: ALDH1A inhibition sensitizes colon cancer cells to chemotherapy
IC50 | CAP (μg/ml) | 5-FU (μg/ml) | RAL (μg/ml) | IRI (μg/ml) |
|---|---|---|---|---|
HCT-116/eGFP | ||||
 negat siRNA | 296.13 (r = 0.993) | 0.28 (r = 0.985) | 1.88 (r = 1.000) | 0.03 (r = 0.971) |
 ALDH1A3 siRNA | 300.00 (r = 0.987) | 0.21 (r = 0.992) | 1.79 (r = 1.000) | 0.10 (r = 0.924) |
HT-29/eGFP | ||||
 negat siRNA | 240.34 (r = 1.00) | 0.044 (r = 0.997) | 0.83 (r = 0.998) | 1.43 (r = 0.999) |
 ALDH1A1 siRNA | 64.27 (r = 0.955) | 0.0008 (r = 0.866) | 0.81 (r = 0.998) | 1.53 (r = 0.998) |
LS-180/eGFP | ||||
 negat siRNA | 267.86 (r = 0.952) | 0.70 (r = 0.454) | 2.06 (r = 1.000) | 0.262 (r = 0.893) |
 ALDH1A1 siRNA | 927.74 (r = 0.999) | 3.07 (r = 0.986) | 1.76 (r = 1.000) | 3.46 (r = 0.998) |