Fig. 4

Hyaluronan, CD44, HYAL2, HAS1, HAS2 and HAS3 staining intensities in gliomas according to WHO grade. There are no statistically significant differences between the groups in hyaluronan (a) and CD44 (b) stainings. Intensity of HYAL2 staining increases according to WHO grade (c). HAS1 staining intensity is higher in grade IV astrocytomas compared to grade II and III astrocytomas (d). HAS2 staining intensity increases in grade IV astrocytomas compared to grade II-III astrocytomas (e). Most of the samples are HAS3 negative or the staining intensity is weak (f). * = p-value < 0.05, ** = p-value < 0.01