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Table 2 Multivariable adjusted hazard ratios for overall mortality by pre-diagnostic lipids and breast cancer molecular subtypes

From: Impact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypes

  All cases (eventsa=129) Luminal A (eventsa=45) Luminal B (eventsa=29) HER2-enriched (eventsa=17) TNBC (eventsa=38)
n HR (95% CI) n HR (95% CI) n HR (95% CI) n HR (95% CI) n HR (95% CI)
Triglycerides
 Continuous, mmol/l 464 1.01 (0.88–1.22) 228 0.99 (0.56–1.75) 99 1.64 (0.78–3.46) 43 0.06 (0.01–0.77) 94 1.02 (0.83–1.24)
Tertiles
  ≤ 0.82 mmol/l 153 1.00 77 1.00 33 1.00 14 1.00 29 1.00
 0.83–1.22 mmol/l 158 0.69 (0.42–1.11) 78 1.19 (0.53–2.66) 33 0.50 (0.17–1.46) 14 0.13 (0.03–0.64) 33 0.96 (0.35–2.62)
  ≥ 1.23 mmol/l 153 1.24 (0.78–1.99) 73 1.26 (0.57–2.78) 33 1.01 (0.36–2.78) 15 0.06 (0.01–0.55) 32 2.99 (1.17–7.63)
p-trend   0.351   0.838   0.179   0.001   0.011
Total-cholesterol
Continuous, mmol/l 464 1.03 (0.90–1.19) 228 1.06 (0.83–1.36) 99 1.00 (0.66–1.51) 43 1.05 (0.70–1.57) 94 1.05 (0.77–1.44)
Tertiles
  ≤ 5.14 mmol/l 155 1.00 77 1.00 37 1.00 11 1.00 30 1.00
 5.15–6.25 mmol/l 156 1.33 (0.80–2.22) 82 1.66 (0.70–3.95) 27 0.85 (0.29–2.50) 16 1.28 (0.18–7.93) 31 1.01 (0.39–2.67)
  ≥ 6.26 mmol/l 153 1.46 (0.87–2.44) 69 1.48 (0.61–3.60) 35 1.20 (0.38–3.72) 16 2.04 (0.34–12.3) 33 1.41 (0.49–4.06)
p-trend   0.354   0.512   0.830   0.533   0.731
HDL-cholesterol/total-cholesterol ratio
Continuous, 464 0.89 (0.58–1.36) 228 0.68 (0.02–25.0) 99 0.23 (0.01–54.2) 43 693 (0.06–747) 94 0.02 (0.00–1.39)
Tertiles
  ≤ 0.27 154 1.00 76 1.00 32 1.00 21 1.00 25 1.00
 0.28–0.34 154 0.84 (0.65–1.29) 67 0.81 (0.37–1.79) 37 1.48 (0.57–3.87) 14 1.53 (0.45–5.23) 36 0.53 (0.24–1.19)
  ≥ 0.35 156 0.82 (0.51–1.33) 85 1.05 (0.43–2.00) 30 0.96 (0.33–2.74) 8 5.61 (0.62–21.0) 33 0.33 (0.12–0.89)
p-trend   0.385   0.819   0.986   0.176   0.026
  1. Multivariable Cox proportional hazard regression models
  2. aNumber of deaths
  3. Adjusted for age (continuous), Body mass index (continuous), and current smoking (categorical) at blood sampling, age at diagnosis (continuous), and disease stage (categorical)
  4. Abbreviations: HDL high density lipoprotein, HR hazard ratio; n number of cases, t Total, TNBC triple negative breast cancer