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Table 5 Factors affecting ORR achievement by logistic regression analysis

From: Efficacy and safety profile of drug-eluting beads transarterial chemoembolization by CalliSpheres® beads in Chinese hepatocellular carcinoma patients

Parameters Univariate logistic regression Multivariate logistic regression
P value OR 95% CI P value OR 95% CI
Lower Higher Lower Higher
Age > =60 years 0.328 0.630 0.250 1.590
Gender (male) 0.655 1.388 0.329 5.847
HBV 0.821 0.772 0.082 7.258
HCV 0.415 0.311 0.019 5.168
Drink 0.841 1.100 0.434 2.790
Cirrhosis 0.753 0.861 0.340 2.183
Tumor distribution > = 20% 0.765 0.993 0.384 2.566
Number of nodules > 1 0.103 0.377 0.117 1.219
Number of nodules > 3 0.058 0.400 0.155 1.031 0.381 0.618 0.211 1.813
Largest nodule size > 3 cm 0.270 1.692 0.664 4.313
Largest nodule size > 5 cm 0.785 0.879 0.349 2.216
Portal vein invasion 0.130 0.475 0.181 1.246
Hepatic vein invasion 0.526 0.686 0.213 2.204
ECOG = 1 (vs. 0) 0.596 1.327 0.466 3.778
Child-pugh stage B (vs. stage A) 0.432 2.368 0.276 20.285
Higher BCLC stage 0.073 0.560 0.297 1.056 0.178 0.600 0.285 1.262
AFP abnormal 0.432 0.745 0.290 1.918
Previous cTACE 0.093 0.449 0.177 1.142 0.095 0.433 0.162 1.158
Previous surgery 0.139 2.038 0.793 5.241
Previous systematic chemotherapy 0.821 1.296 0.138 12.186
Previous radiofrequency ablation 0.586 0.724 0.226 2.315
Previous targeted therapy
Epirubicin (vs. Adriamycin)
  1. Data was presented as P value, OR (odds ratio) and 95% CI. Factors affecting ORR achievement were determined by univariate logistic regression analysis, while all factors with P value no less than 0.1 were further detected by multivariate logistic regression analysis. P Value < 0.05 was considered significant. Previous targeted therapy and Epirubicin (vs Adriamycin) were not able to be analyzed due to lack of effective events. BCLC score was defined as 0-Stage A, 1-Stage B, 2-Stage C to be analyzed in logistic model. HBV Hepatic b virus, HCV Hepatic c virus, ECOG Eastern Cooperative Oncology Group, BCLC Barcelona Clinic Liver Cancer, AFP Alpha fetal protein, cTACE Conventional transarterial chemo-embolization