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Fig. 4 | BMC Cancer

Fig. 4

From: S100A4 suppresses cancer stem cell proliferation via interaction with the IKK/NF-κB signaling pathway

Fig. 4

S100A4 promoted NF-κB transcriptional activity. a Luciferase reporter assay of NF-κB transcriptional activity showed that MCSCs transfected with S100A4-vector exhibited enhanced transcriptional activity of a NF-κB reporter gene. b Luciferase reporter assay showed that MCSCs transfected with S100A4-siRNA exhibited decreased NF-κB transcriptional activity. c Western blotting analysis of the expression of IKK; β-actin was used as a negative control. d Quantitative PCR analysis showed that the expression of IL-2 and TNF were up-regulated in MCSCs transfected with S100A4-vector. e Quantitative PCR analysis showed that the expression of IL-2 and TNF were down-regulated in MCSCs transfected with S100A4-siRNA. Data is mean ± SD of three independent experiments. * P < 0.05

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BMC Cancer

ISSN: 1471-2407

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