Table 1 Patient and tumour characteristics of ER-positive postmenopausal breast cancer patients as whole and according to BMI categories
Total cases N = 460 | BMI < 25 N = 195 | BMI 25–30 N = 141 | BMI ≥30 N = 78 | p-valuea | |
|---|---|---|---|---|---|
Histology | |||||
IDC | 350 (76.9%) | 135 (71.1%) | 113 (80.1%) | 65 (83.3%) | 0.132 |
IDC + ILC | 42 (9.2%) | 19 (10.0%) | 12 (8.5%) | 6 (7.7%) | |
ILC | 63 (13.8%) | 36 (18.9%) | 16 (11.3%) | 7 (9.0%) | |
Other | 5 | 5 | 0 | 0 | |
Tumour size | |||||
pT1 | 306 (67.1%) | 137 (71.7%) | 92 (65.2%) | 46 (59.0%) | 0.167 |
pT2 | 121 (26.5%) | 41 (21.5%) | 42 (29.8%) | 24 (30.8%) | |
pT3-pT4 | 29 (6.4%) | 13 (6.8%) | 7 (5.0%) | 8 (10.3%) | |
NA | 4 | 4 | 0 | 0 | |
Tumour grade | |||||
G1 | 35 (7.7%) | 18 (9.4%) | 9 (6.4%) | 4 (5.1%) | 0.166 |
G2 | 293 (64.4%) | 129 (67.2%) | 82 (58.6%) | 51 (65.4%) | |
G3 | 127 (27.9%) | 45 (23.4%) | 49 (35.0%) | 23 (29.5%) | |
NA | 5 | 3 | 1 | 0 | |
Nodal status | |||||
Negative | 288 (64.3%) | 122 (64.2%) | 83 (61.5%) | 44 (57.1%) | 0.689 |
Positive (1–2) | 88 (19.6%) | 34 (17.9%) | 31 (23.0%) | 18 (23.4%) | |
Positive (> 2) | 72 (16.1%) | 34 (17.9%) | 21 (15.6%) | 15 (19.5%) | |
NA | 12 | 5 | 6 | 1 | |
Progesterone receptor status | |||||
Negative | 103 (22.4%) | 52 (26.7%) | 24 (17.0%) | 11 (14.1%) | 0.025 |
Positive | 357 (77.6%) | 143 (73.3%) | 117 (83.0%) | 67 (85.9%) | |
Androgen receptor status | |||||
Negative | 37 (8.5%) | 18 (9.9%) | 15 (10.9%) | 2 (2.7%) | 0.099 |
Positive < 60% | 162 (37.1%) | 70 (38.5%) | 50 (36.5%) | 22 (29.7%) | |
Positive ≥60% | 238 (54.5%) | 94 (51.6%) | 72 (52.6%) | 50 (67.6%) | |
NA | 23 | 13 | 4 | 4 | |
HER2 status | |||||
Negative | 176 (55.5%) | 78 (56.5%) | 51 (51.0%) | 27 (56.2%) | 0.520 |
Positive 2+ | 90 (28.4%) | 42 (30.4%) | 28 (28.0%) | 15 (31.2%) | |
Positive 3+ | 51 (16.1%) | 18 (13%) | 21 (21.0%) | 6 (12.5%) | |
NA | 143 | 57 | 41 | 30 | |
Endocrine therapy | |||||
No | 30 (6.5%) | 14 (7.2%) | 6 (4.3%) | 5 (6.4%) | 0.543 |
Yes | 429 (93.5%) | 181 (92.8%) | 134 (95.7%) | 73 (93.6%) | |
NA | 1 | 0 | 1 | 0 | |