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Table 3 Adjusted and unadjusted odds ratios and 95% confidence intervals for the association of urinary concentrations of organophosphate flame retardants (ng/ml; specific gravity-corrected) and papillary thyroid cancer in Connecticut women

From: A case-control study of exposure to organophosphate flame retardants and risk of thyroid cancer in women

Organophosphate flame retardant (ng/ml) Cases Controls Unadjusted OR (95% CI) p- trend Adjusted OR (95% CI)a p-trend
BCIPP       
  < MDL 61 50 1   1  
  ≥ MDL - 0.45 26 25 0.85 (0.44, 1.66)   0.72 (0.34, 1.54) 0.06
  > 0.45 13 25 0.43 (0.19, 0.91) 0.04 0.44 (0.18, 1.03)
 Continuousb 100 100 0.88 (0.77, 1.01)   0.89 (0.76, 1.04)  
DPHP       
  < 0.59 34 33 1   1  
 0.59–1.28 34 33 1.00 (0.51, 1.97)   1.02 (0.47, 2.22) 0.88
  > 1.28 32 34 0.91 (0.46, 1.80) 0.80 1.06 (0.49, 2.29)
 Continuousb 100 100 0.94 (0.72, 1.21)   0.99 (0.74, 1.31)  
BDCIPP       
  < 0.37 31 33 1   1  
 0.37–0.96 28 33 1.17 (0.59, 2.35)   1.08 (0.50, 2.36) 0.46
  > 0.96 41 34 1.24 (0.63, 2.46) 0.54 1.33 (0.62, 2.86)
 Continuousb 100 100 1.07 (0.87, 1.31)   1.07 (0.85, 1.34)  
IPDPP       
  < 1.60 32 33 1   1  
 1.60–3.56 26 33 0.90 (0.45, 1.83)   0.89 (0.41, 1.59) 0.66
  > 3.56 42 34 1.28 (0.66, 2.51) 0.45 1.17 (0.54, 2.54)
 Continuousb 100 100 1.12 (0.83, 1.52)   1.06 (0.75, 1.48)  
BCIPHIPP       
  < 0.12 38 33 1   1  
 0.12–0.32 34 33 0.89 (0.46, 1.75)   0.92 (0.44, 1.93) 0.30
  > 0.32 28 34 0.72 (0.36, 1.41) 0.34 0.66 (0.30, 1.42)
 Continuousb 100 100 0.85 (0.69, 1.03)   0.82 (0.65, 1.01)  
Summed PFR       
  < 4.10 35 34 1   1  
 4.10–7.95 29 33 0.85 (0.43, 1.70)   0.94 (0.43, 2.00)  
  > 7.95 36 33 1.06 (0.54, 2.07) 0.87 1.07 (0.50, 2.31) 0.86
 Continuousb 100 100 0.96 (0.71, 1.31)   0.93 (0.65, 1.33)  
  1. bis(1-chloro-2-propyl) 1-hydroxy-2-propyl phosphate (BCIPHIPP), bis(1-chloro-2-propyl) phosphate (BCIPP), diphenyl phosphate (DPP), bis(1,3-dichloro-2-propyl) phosphate (BDCIPP), isopropyl-phenyl phenyl phosphate (IP-PPP), and tert-butyl phenyl phenyl phosphate (tb-PPP), odds ratio (OR), 95% confidence interval (95% CI), PFR (organophosphate flame retardant)
  2. aAdjusted for age, BMI, education level, family history of thyroid cancer, previous benign thyroid disease, and alcohol consumption
  3. bOdds ratio calculated for each 1og of 1 ng/ml
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