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Table 6 MDR analysis for the prediction of HCC risk with and without haplotype AG

From: A rare CHD5 haplotype and its interactions with environmental factors predicting hepatocellular carcinoma risk

Best interaction models Cross-validation Average prediction error P a
Distcovery study
 1 99/100 0.385 < 0.0001
 1,2 96/100 0.403 < 0.0001
 1,2,3 100/100 0.401 < 0.0001
 1,2,3,4 87/100 0.380 < 0.0001
 1,2,3,4,5b 100/100 0.378 < 0.0001
Replication study
 1 95/100 0.412 < 0.0001
 1,2 94/100 0.417 < 0.0001
 1,2,3 98/100 0.389 < 0.0001
 1,2,3,4 90/100 0.383 < 0.0001
 1,2,3,4,5b 100/100 0.368 < 0.0001
Combined study
 1 96/100 0.399 < 0.0001
 1,2 94/100 0.410 < 0.0001
 1,2,3 99/100 0.396 < 0.0001
 1,2,3,4 89/100 0.382 < 0.0001
 1,2,3,4,5b 100/100 0.375 < 0.0001
  1. Labels: 1, drinking status; 2, haplotype AG (block 3); 3, age; 4, smoking status; 5, gender
  2. aP value for 1000-fold permutation test
  3. bThe best model with maximum cross-validation consistency and minimum prediction error rate