A rare CHD5 haplotype and its interactions with environmental factors predicting hepatocellular carcinoma risk

BMC Cancer

Table 6 MDR analysis for the prediction of HCC risk with and without haplotype AG

Best interaction models	Cross-validation	Average prediction error	P ^a
Distcovery study
1	99/100	0.385	< 0.0001
1,2	96/100	0.403	< 0.0001
1,2,3	100/100	0.401	< 0.0001
1,2,3,4	87/100	0.380	< 0.0001
1,2,3,4,5^b	100/100	0.378	< 0.0001
Replication study
1	95/100	0.412	< 0.0001
1,2	94/100	0.417	< 0.0001
1,2,3	98/100	0.389	< 0.0001
1,2,3,4	90/100	0.383	< 0.0001
1,2,3,4,5^b	100/100	0.368	< 0.0001
Combined study
1	96/100	0.399	< 0.0001
1,2	94/100	0.410	< 0.0001
1,2,3	99/100	0.396	< 0.0001
1,2,3,4	89/100	0.382	< 0.0001
1,2,3,4,5^b	100/100	0.375	< 0.0001

Labels: 1, drinking status; 2, haplotype AG (block 3); 3, age; 4, smoking status; 5, gender
^aP value for 1000-fold permutation test
^bThe best model with maximum cross-validation consistency and minimum prediction error rate

ISSN: 1471-2407